Regional variation of ankle and hindfoot cartilage T2 mapping values at 3 T: A feasibility study

Lockard, Carly A.; Chang, Angela; Shin, Richard C.; Clanton, Thomas O.; Ho, Charles P.

doi:10.1016/j.ejrad.2019.02.011

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…Ankle MRI allows noninvasive evaluation of macroscopic and ultrastructure composition/organization cartilage changes. 10,11 Quantitative MRI such as T2, 10-13 T2*, 14 T1rho, 15 dGEMRIC, 11,16 sodium, 17 and gagCEST 18 mapping provide compositional information about cartilage tissue health and repair tissue quality, 17,19,20 while morphological sequences provide information about macroscopic characteristics such as synovitis, chondral/osteochondral lesions, subchondral bone cysts, and bone marrow edema. 10,11,21…”

Section: Introductionmentioning

confidence: 99%

Accuracy of MRI-Based Talar Cartilage Thickness Measurement and Talus Bone and Cartilage Modeling: Comparison with Ground-Truth Laser Scan Measurements

et al. 2020

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Objective The purpose of this work was to compare measurements of talar cartilage thickness and cartilage and bone surface geometry from clinically feasible magnetic resonance imaging (MRI) against high-accuracy laser scan models. Measurement of talar bone and cartilage geometry from MRI would provide useful information for evaluating cartilage changes, selecting osteochondral graft sources or creating patient-specific joint models. Design Three-dimensional (3D) bone and cartilage models of 7 cadaver tali were created using (1) manual segmentation of high-resolution volumetric sequence 3T MR images and (2) laser scans. Talar cartilage thickness was compared between the laser scan– and MRI-based models for the dorsal, medial, and lateral surfaces. The laser scan– and MRI-based cartilage and bone surface models were compared using model-to-model distance. Results Average cartilage thickness within the dorsal, medial, and lateral surfaces were 0.89 to 1.05 mm measured with laser scanning, and 1.10 to 1.22 mm measured with MRI. MRI-based thickness was 0.16 to 0.32 mm higher on average in each region. The average absolute surface-to-surface differences between laser scan– and MRI-based bone and cartilage models ranged from 0.16 to 0.22 mm for bone (MRI bone models smaller than laser scan models) and 0.35 to 0.38 mm for cartilage (MRI bone models larger than laser scan models). Conclusions This study demonstrated that cartilage and bone 3D modeling and measurement of average cartilage thickness on the dorsal, medial, and lateral talar surfaces using MRI were feasible and provided similar model geometry and thickness values to ground-truth laser scan–based measurements.

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Section: Introductionmentioning

confidence: 99%

Accuracy of MRI-Based Talar Cartilage Thickness Measurement and Talus Bone and Cartilage Modeling: Comparison with Ground-Truth Laser Scan Measurements

et al. 2020

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“…A further limitation is that cartilage T2 values may have regional variations, as detected with a 3 T scanner, 36 which may increase the analysis error. Since both medial and lateral surgical sites were present in our datasets, the T2 values we reported for the different tissue types are also affected by this error.…”

Section: Discussionmentioning

confidence: 99%

“…While this was sufficient to evidence a statistical difference in T2 between the two treatment subgroups, further analyses (eg, correlation between T2 and clinical or imaging scores) are needed in larger cohorts of patients. 10,15 A further limitation is that cartilage T2 values may have regional variations, as detected with a 3 T scanner, 36 which may increase the analysis error. Since both medial and lateral surgical sites were present in our datasets, the T2 values we reported for the different tissue types are also affected by this error.…”

Section: Limitationsmentioning

confidence: 99%

Quantitative MRI T2 Mapping is Able to Assess Tissue Quality After Reparative and Regenerative Treatments of Osteochondral Lesions of the Talus

Rizzo

Cristoforetti

Marinetti

et al. 2021

Magnetic Resonance Imaging

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“…Lockard et al . found that the average T2 values of ankle cartilage and hind foot were significantly different in normal volunteers [ 17 ]. Our results of TT cartilage were consistent with previous study, which might be due to the magic angle effect and the different gravity load [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of ankle cartilage in asymptomatic adolescent football players after season by T2-mapping magnetic resonance imaging

Luo

Cao

et al. 2021

BioMed Eng OnLine

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Background Ankle sprain affects the structure and function of ankle cartilage. However, it is not clear whether the daily training and competition affect the ankle cartilage without acute injury. Changes in ankle cartilage without injury may influence future strategies to protect ankle function in athletes. This study aimed to evaluate whether the composition of ankle cartilage significantly altered in asymptomatic adolescent football players after a whole season of training and competition using T2-mapping magnetic resonance imaging (MRI). Materials and methods 12 local club’s U17 asymptomatic adolescent football players without abnormalities in routine MRI were included. Routine and T2-mapping MRI were performed to measure the cartilage thickness of tibiotalar joint (TT) and posterior subtalar joint (pST) and T2 values in pre- and post-seasons. All of them took the right side as dominant foot. Results In the pre- and post-seasons, cartilage T2 values in TT (talus side) and pST (calcaneus side) were higher than that of TT (tibial side) and pST (talus side) (all p < 0.05), which was caused by magic angle effect and gravity load. No statistically significant differences in thickness after season in the other cartilages of ankle were found compared with that before the season (all p > 0.05). However, T2 values of TT (tibial side and talus side) cartilage in the dominant foot were significantly reduced after season (p = 0.008; p = 0.034). These results indicate that the microstructure of articular cartilage changes in the joints with greater mobility, although no trauma occurred and the gross morphology of cartilage did not change. Conclusion Changes in the T2 values of tibiotalar joint cartilage in the dominant foot of healthy young athletes before and after the season suggest that the microstructure of cartilage had changed during sports even without injury. This finding suggests that the dominant ankle joint should be protected during football to delay degeneration of the articular cartilage.

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Regional variation of ankle and hindfoot cartilage T2 mapping values at 3 T: A feasibility study

Cited by 8 publications

References 32 publications

Accuracy of MRI-Based Talar Cartilage Thickness Measurement and Talus Bone and Cartilage Modeling: Comparison with Ground-Truth Laser Scan Measurements

Accuracy of MRI-Based Talar Cartilage Thickness Measurement and Talus Bone and Cartilage Modeling: Comparison with Ground-Truth Laser Scan Measurements

Quantitative MRI T2 Mapping is Able to Assess Tissue Quality After Reparative and Regenerative Treatments of Osteochondral Lesions of the Talus

Quantitative evaluation of ankle cartilage in asymptomatic adolescent football players after season by T2-mapping magnetic resonance imaging

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