Regional variation of white matter development in the cat brain revealed by ex vivo diffusion MR tractography

Dai, Guangping; Das, Avilash; Hayashi, Emiko; Chen, Qin; Takahashi, Emi

doi:10.1016/j.ijdevneu.2016.08.004

Cited by 7 publications

(15 citation statements)

References 29 publications

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“…Although the majority of the callosal fibers projected dorsally, in a concave fashion, there was a well-represented group of ventrally oriented fibers connecting the temporal lobes which correspond to the tapetum. This structure is similar to that observed in previous tractography descriptions (Dai et al, 2016).…”

Section: Commissural Tractsupporting

confidence: 90%

“…The fibers are in close relation to the cerebral ventricles in multiple section planes. The structure of the fornix identified is consistent with that dissected anatomically and described with tractography (Dai et al, 2016;Jacqmot et al, 2017;Pascalau et al, 2018).…”

Section: Fornixsupporting

confidence: 77%

“…The cingulum tracked appropriately along the cingulate gyri and exhibited frontal connectivity consistent with that described in gross anatomic dissections and tractography (Dai et al, 2016;Pascalau et al, 2016 ; Figures 2, 4G-I). Mean tract length was relatively low [left 15.66 ± 9.2 and right (16.5 ± 11.6)], likely due to the short radiating fibers that extend dorsally from the cingulum ( Table 1).…”

Section: Cingulumsupporting

confidence: 68%

“…White matter tract reconstructions were performed using the FACT algorithm (Mori et al, 1999) with a step length of 0.5 mm and angle threshold of 35 • in TrackVis (Wang et al, 2007) within a binary brain mask. The ROI seed placement adapted from that described by Catani and Thiebaut de Schotten (2008) and feline tractography descriptions (Dai et al, 2016;Jacqmot et al, 2017). Seed regions were delineated on the FA maps and once tracts were generated obvious spurious tracts were removed.…”

Section: White Matter Tractographymentioning

confidence: 99%

“…Both these forms of tractography have been used to create functional white matter brain maps that are routinely used, in the human, rhesus macaque, rat, mouse, dog and ferret research (Mori et al, 2008;Jiang and Johnson, 2011;Rumple et al, 2013;Zakszewski et al, 2014;Calabrese et al, 2015;Robinson et al, 2016;Hutchinson et al, 2017). Tractography techniques have been used to document the anatomy of feline white matter tracts (Jacqmot et al, 2017) and evaluate the development and regional variation of white matter in the juvenile feline brain (Takahashi et al, 2009;Dai et al, 2016). These articles have provided information on the location and diffusivity characteristics of several pathways; however, these previous articles do not compare in vivo tract reconstructions with ex vivo gross anatomic dissection.…”

Section: Introductionmentioning

confidence: 99%

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Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

et al. 2020

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The cat brain is a useful model for neuroscientific research and with the increasing use of advanced neuroimaging techniques there is a need for an open-source stereotaxic white matter brain atlas to accompany the cortical gray matter atlas, currently available. A stereotaxic white matter atlas would facilitate anatomic registration and segmentation of the white matter to aid in lesion localization or standardized regional analysis of specific regions of the white matter. In this article, we document the creation of a stereotaxic feline white matter atlas from diffusion tensor imaging (DTI) data obtained from a population of eight mesaticephalic felines. Deterministic tractography reconstructions were performed to create tract priors for the major white matter projections of Corpus callosum (CC), fornix, cingulum, uncinate, Corona Radiata (CR), Corticospinal tract (CST), inferior longitudinal fasciculus (ILF), Superior Longitudinal Fasciculus (SLF), and the cerebellar tracts. T1-weighted, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) population maps were generated. The volume, mean tract length and mean FA, MD, AD and RD values for each tract prior were documented. A structural connectome was then created using previously published cortical priors and the connectivity metrics for all cortical regions documented. The provided white matter atlas, diffusivity maps, tract priors and connectome will be a valuable resource for anatomical, pathological and translational neuroimaging research in the feline model. Multi-atlas population maps and segmentation priors are available at Cornell's digital repository: https://ecommons.cornell.edu/handle/1813/58775.2.

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Section: Commissural Tractsupporting

confidence: 90%

Section: Fornixsupporting

confidence: 77%

Section: Cingulumsupporting

confidence: 68%

Section: White Matter Tractographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

et al. 2020

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Brain Lateralization: A Comparative Perspective

Güntürkün

Ströckens

Ocklenburg

2020

Physiological Reviews

295

188

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Comparative studies on brain asymmetry date back to the 19th century but then largely disappeared due to the assumption that lateralization is uniquely human. Since the reemergence of this field in the 1970s, we learned that left-right differences of brain and behavior exist throughout the animal kingdom and pay off in terms of sensory, cognitive, and motor efficiency. Ontogenetically, lateralization starts in many species with asymmetrical expression patterns of genes within the Nodal cascade that set up the scene for later complex interactions of genetic, environmental, and epigenetic factors. These take effect during different time points of ontogeny and create asymmetries of neural networks in diverse species. As a result, depending on task demands, left- or right-hemispheric loops of feedforward or feedback projections are then activated and can temporarily dominate a neural process. In addition, asymmetries of commissural transfer can shape lateralized processes in each hemisphere. It is still unclear if interhemispheric interactions depend on an inhibition/excitation dichotomy or instead adjust the contralateral temporal neural structure to delay the other hemisphere or synchronize with it during joint action. As outlined in our review, novel animal models and approaches could be established in the last decades, and they already produced a substantial increase of knowledge. Since there is practically no realm of human perception, cognition, emotion, or action that is not affected by our lateralized neural organization, insights from these comparative studies are crucial to understand the functions and pathologies of our asymmetric brain.

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Beyond the surface: how ex-vivo diffusion-weighted imaging reveals large animal brain microstructure and connectivity

Behroozi,

Graïc,

Gerussi

2024

Front. Neurosci.

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Diffusion-weighted Imaging (DWI) is an effective and state-of-the-art neuroimaging method that non-invasively reveals the microstructure and connectivity of tissues. Recently, novel applications of the DWI technique in studying large brains through ex-vivo imaging enabled researchers to gain insights into the complex neural architecture in different species such as those of Perissodactyla (e.g., horses and rhinos), Artiodactyla (e.g., bovids, swines, and cetaceans), and Carnivora (e.g., felids, canids, and pinnipeds). Classical in-vivo tract-tracing methods are usually considered unsuitable for ethical and practical reasons, in large animals or protected species. Ex-vivo DWI-based tractography offers the chance to examine the microstructure and connectivity of formalin-fixed tissues with scan times and precision that is not feasible in-vivo. This paper explores DWI’s application to ex-vivo brains of large animals, highlighting the unique insights it offers into the structure of sometimes phylogenetically different neural networks, the connectivity of white matter tracts, and comparative evolutionary adaptations. Here, we also summarize the challenges, concerns, and perspectives of ex-vivo DWI that will shape the future of the field in large brains.

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Regional variation of white matter development in the cat brain revealed by ex vivo diffusion MR tractography

Cited by 7 publications

References 29 publications

Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

Brain Lateralization: A Comparative Perspective

Beyond the surface: how ex-vivo diffusion-weighted imaging reveals large animal brain microstructure and connectivity

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