Regional variations of vertebral trabecular bone microstructure with age and gender

Chen, Huayue; Shoumura, Shízuko; Emura, S.; Bunai, Yasuo

doi:10.1007/s00198-008-0593-3

Cited by 92 publications

(109 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is crucial to reduce the inconsistency, render the experiments reproducible and shift the focus onto understanding the influence of viscosity and structure on the flow behaviour. The pore spacing of the Osteo surrogates (0.89 ± 0.03 mm) was comparable to that reported in the literature for human osteoporotic vertebral cancellous bone [23][24][25][26][27], suggesting that the surrogates were pathologically representative. The boundary of the surrogates simulated the vertebral shell which confines the flow and controls the intravertebral pressure, significantly affecting the filling pattern [28].…”

Section: Discussionsupporting

confidence: 81%

Novel methodology for assessing biomaterial–biofluid interaction in cancellous bone

Bou-Francis

Soyka

Ferguson

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 81%

Novel methodology for assessing biomaterial–biofluid interaction in cancellous bone

Bou-Francis

Soyka

Ferguson

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

“…It has a spatial resolution (10 lm range), which is 10-100 times better than conventional clinical CT or MRI scanners, and can accurately differentiate between the trabecular and cortical bone compartments and non-osseous tissues, as opposed to conventional clinical CT and MRI imaging [14,26,27,29]. Although it has been used in spine studies previously, it has never been used to study in Modic changes before [30][31][32]. It is typically used for ex vivo scanning of excised human and animal bones [14,29] or in vivo scanning of small animals, at micrometer resolution [33].…”

Section: Discussionmentioning

confidence: 99%

“…This finding in Modic changes is different from that for normal (non-pathological) vertebral bone reported in the literature, where, in bone extracted from similar anatomical locations within the vertebrae and examined with histology and micro-CT, the trabecular BV/ TV shows significant decrease with age (e.g., R 2 = 0.61, p \ 0.05, age range 23-95 years; or R 2 = 0.61, p \ 0.05, age range 57-98 years) [30,53]. The absence of correlation with age in Modic changes in our study is a novel finding, and is likely linked to the increased remodelling activity found in the bone.…”

Section: Discussionmentioning

confidence: 99%

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

et al. 2014

View full text Add to dashboard Cite

Purpose In the literature, inter-vertebral MRI signal intensity changes (Modic changes) were associated with corresponding histological observations on endplate biopsies. However, tissue-level studies were limited. No quantitative histomorphometric study on bone biopsies has yet been conducted for Modic changes. The aim of this study was to characterise the bone micro-architectural parameters and bone remodelling indices associated with Modic changes. Methods Forty patients suffering from disabling low back pain, undergoing elective spinal surgery, and exhibiting Modic changes on MRI (Modic 1, n = 9; Modic 2, n = 25; Modic 3, n = 6), had a transpedicular vertebral body biopsy taken of subchondral bone. Biopsies were first examined by micro-CT, for 3D morphometric analysis of bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation, trabecular number, and structure model index. Then, samples underwent histological analysis, for determination of bone remodelling indices: osteoid surface to bone surface ratio (OS/BS), eroded surface to bone surface (ES/BS) and osteoid surface to eroded surface ratio (OS/ES). Results Micro-CT analysis revealed significantly higher BV/TV (up to 70 % increase, p \ 0.01) and Tb.Th (up to ?57 %, p \ 0.01) in Modic 3 biopsies, compared to Modic 1 and 2. Histological analysis showed significantly lower OS/BS in Modic 2 biopsies (more than 28 % decrease, p \ 0.05) compared to 1 and 3. ES/BS progressively decreased from Modic 1 to 2 to 3, whereas OS/ES progressively increased with significantly higher values in Modic 3 (up to 159 % increase, p \ 0.05) than in Modic 1 and 2. Conclusions Significant differences were found in bone micro-architectural parameters and remodelling indices among Modic types. Modic 1 biopsies had evidence of highest bone turnover, possibly due to an inflammatory process; Modic 2 biopsies were consistent with a reduced bone formation/remodelling stage; Modic 3 biopsies suggested a more stable sclerotic phase, with significantly increased BV/TV and Tb.Th compared to Modic 1 and 2, linked to increased bone formation and reduced resorption.

show abstract

“…It has been confirmed that the architecture of the trabecular bone within the vertebral body is inhomogeneous (17,(28)(29)(30)(31). Within the vertebral body, the trabecular architecture in the posterior region was superior to the anterior region (28,31).…”

Section: Discussionmentioning

confidence: 82%

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Wen

Yan

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Assessing the biomechanical properties of trabecular bone is of major biological and clinical significance for the research of bone diseases, fractures and their treatments. Micro-finite element (µFE) models are becoming increasingly popular for investigating the biomechanical properties of trabecular bone. The shapes of µFE models typically include cube and cylinder. Whether there are differences between cubic and cylindrical µFE models has not yet been studied. In the present study, cubic and cylindrical µFE models of human vertebral trabecular bone were constructed. A 1% strain was prescribed to the model along the superior-inferior direction. E values were calculated from these models, and paired t-tests were performed to determine whether these were any differences between E values obtained from cubic and cylindrical models. The results demonstrated that there were no statistically significant differences in the E values between cubic and cylindrical models, and there were no significant differences in Von Mises stress distributions between the two models. These findings indicated that, to construct µFE models of vertebral trabecular bone, cubic or cylindrical models were both feasible. Choosing between the cubic or cylindrical µFE model is dependent upon the specific study design.

show abstract

Regional variations of vertebral trabecular bone microstructure with age and gender

Cited by 92 publications

References 49 publications

Novel methodology for assessing biomaterial–biofluid interaction in cancellous bone

Novel methodology for assessing biomaterial–biofluid interaction in cancellous bone

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Contact Info

Product

Resources

About