Regionalanästhesie zur postoperativen und posttraumatischen Schmerzbekämpfung

Niesel, Hans Christoph

doi:10.1007/978-3-642-67127-2_22

Cited by 4 publications

(1 citation statement)

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“…Similar effects on bile flow, oxygen consumption, and potassium release were seen for 10 g/mL bupivacaine and lidocaine, except that the change in potassium release after application of lidocaine did not reach the level of significance (Figs. [2][3][4]. The data obtained with small concentrations of 1 g/mL also revealed a tendency towards an increase in bile flow and oxygen consumption after application of the drugs, but, at this smaller concentration, the choleretic effect was significant only for bupivacaine and lidocaine.…”

Section: Resultsmentioning

confidence: 61%

The Effects of Local Anesthetics on Bile Flow, Potassium Equilibrium and Oxygen Consumption in the Perfused Rat Liver

Felleiter¹,

Lierz²,

Graf³

2006

Anesthesia &Amp; Analgesia

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Amide local anesthetics mainly undergo hepatic metabolism. Specific applications, such as catheter application for long-term pain therapy, may result in large plasma concentrations. As it is unknown whether local anesthetics influence liver function, we examined the influence of lidocaine, bupivacaine, and ropivacaine in concentrations of 1 and 10 microg/mL on the metabolic activity of the perfused rat liver. At the large concentrations, all three local anesthetics caused an immediate increase of oxygen consumption. Bupivacaine and ropivacaine also transiently reduced potassium release. All drugs increased bile flow; this choleretic effect was also significant for bupivacaine and lidocaine in smaller concentrations. In the smaller concentration, only lidocaine significantly increased oxygen consumption. No significant changes in hepatic venous pH were observed. The results show that acute administration of all three local anesthetics results in significant changes of functional variables of the liver. The observed effects appear to result from mitochondrial uncoupling, uptake of the drugs, biliary secretion of their metabolites, and from inhibition of potassium channels. The data provide no evidence that these acute changes may result in enduring postoperative disturbances of liver function, such as cholestasis or jaundice.

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Section: Resultsmentioning

confidence: 61%