Regnase-1 overexpression as a therapeutic approach of Marfan syndrome

Navigating toward gene therapy in Marfan syndrome: A hope for halting aortic aneurysm

“…in a recent issue of Molecular Therapy Methods and Clinical Development is based on this primordial aim. 2 The authors study an endoribonuclease, Regnase-1, that cleaves the mRNA of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-12, and IL-18. Regnase-1 is a well-known member of the molecular machinery involved in cancer, as it forms part of the anti-inflammatory molecular machinery of defense.…”