Regression of a Primary Pseudo-Tumoral Calcinosis Progressing During 16 Years under Combined Treatment with Acetazolamide and Aluminum Hydroxide: A Case Report

Abstract

Primary pseudo-tumoral calcinosis is a rare genetic disease due to a disorder of phosphorus metabolism characterized by the formation and deposition of calcium phosphate crystals in the peri-articular regions. The treatment is based on the reduction of hyperphosphatemia by hygienic and nutritional measures, hypophosphatemic drugs and surgery. We report the case of a 19-year-old patient followed since the age of 3 years for a primary pseudo-tumoral calcinosis that was resistant to surgery and that had well progressed with aluminum hydroxide and acetazolamide. Treatment combining aluminum hydroxide and acetazolamide with hygienic and nutritional measures seems to be an interesting therapeutic option for this pathology.