Regression of choroidal metastasis secondary to breast carcinoma with adjuvant intravitreal injection of bevacizumab

Yao, Hsin-Yu; Horng, Chi‐Ting; Chen, Jiann‐Torng; Tsai, Ming-Jen

doi:10.1111/j.1755-3768.2009.01684.x

Cited by 21 publications

(19 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Choroidal metastases from lung cancer have been successfully treated with intravenous bevacizumab and chemotherapy 7 and intravitreal bevacizumab with concurrent chemotherapy. 8 There have only been four case reports in the literature where patients with lung 9 and breast [10][11][12] tumours, found to have new choroidal lesions despite systemic therapy, were successfully treated with intravitreal bevacizumab.…”

Section: Discussionmentioning

confidence: 99%

“…6 A few recent case reports have described the management of metastatic choroidal lesions through intravenous and/or intravitreal administration of bevacizumab with encouraging results. [7][8][9][10][11][12] We employed intravitreal bevacizumab in the management of three patients with primitive tumours of the lung and breast who developed choroidal metastases during chemotherapy. The study was approved by the Local Ethics Committee.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series

Fenicia

Abdolrahimzadeh

Mannino

et al. 2014

Eye

View full text Add to dashboard Cite

Purpose Management of choroidal metastases is commonly with systemic chemotherapy; however, if tumours are refractory to treatment and vision is endangered, local therapy modalities are feasible. A novel option is the use of intravitreal bevacizumab. This report presents three cases of choroidal metastatic tumours secondary to lung and breast cancer treated with intravitreal bevazizumab. Patients and methods Three patients with choroidal metastases secondary to lung and breast tumours were treated at the Ophthalmology Unit, University of Rome 'Sapienza', S.Andrea Hospital from January 2009 to August 2012. All patients developed vision loss with diagnosis of chorioidal metastasis during systemic chemotherapy. Off label intravitreal bevacizumab treatment was performed with two 1.25 mg injections in two patients and four injections in one patient at 30-day intervals. Results Vision improved, subretinal fluid resolved, and choroidal tumour regression was obtained in all cases. Follow-up was 6, 9, and 12 months and there were no complications related to treatment. Conclusions Intravitreal bevacizumab administration represented an efficacious therapeutic option with rapid effect in the treatment of choroidal metastatic tumours unresponsive to systemic therapy. It can have a role in the management of these tumours by preventing vision loss and improving the quality of life of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series

Fenicia

Abdolrahimzadeh

Mannino

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

“…Overall, the tumor response rates with systemic treatments appear worse than with EBRT suggesting not to omit radiation therapy. Intravitreal bevacizumab injections have shown some efficacy but the data are yet insufficient to draw conclusions [40].…”

Section: Tumor-specific Systemic and Multimodal Treatmentsmentioning

confidence: 99%

“…Other local treatments like photodynamic therapy, laser, intravitreal injection of antiangiogenic drugs have also been used [34][35][36][37][38][39][40][41]. Photodynamic therapy with verteporfin (which specific target is the vascular endothelium) leads to destroy the tumor by direct effect (mediated by singlet oxygen), vascular damage and autoimmune response activation.…”

Section: Other Local Treatmentsmentioning

confidence: 99%

Management of choroidal metastases

Jardel

Sauerwein²,

Olivier

et al. 2014

Cancer Treatment Reviews

View full text Add to dashboard Cite

“…Lin et al found similar results after offering an intravitreal injection of 4 mg of bevacizumab to a 43-year-old man with a colon adenocarcinoma who developed bone and choroidal metastasis and was on treatment with oxaliplatin and fluorouracil (52). Yao et al recently presented analogous results in a 50-year-old woman with metastasis to the lungs, mediastinal lymph nodes and choroid, treated with paclitaxel, gemcitabine and adjuvant 2.5 mg of intravitreal bevacizumab (53).…”

Section: Anti-vascular Endothelial Growth Factor-targeted Treatmentmentioning

confidence: 74%

Uveal metastatic disease: Current and new treatment options (Review)

Giuliari¹,

Sadaka²

2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ocular metastasis are breast cancer in women and lung cancer in men. In most cases, these lesions tend to be asymptomatic and are not evaluated by an ophthalmologist. The diagnosis is generally made by the history of present or prior malignancies and an ophthalmological examination with slit-lamp biomicroscopy and indirect ophthalmoscopy. As with other malignancies, management may vary with each patient. Small tumors, that do not compromise the vision and that have responded previously to systemic treatment, may be closely observed. For larger lesions and for symptomatic ones, external beam radiation offers an excellent alternative to save the eye and stabilize vision. Bevacizumab (Avastin), a potent monoclonal antibody that has also been employed for the treatment of ocular vaso-proliferative diseases, has been used in the treatment of choroidal metastasis and has shown promising results.

show abstract

Regression of choroidal metastasis secondary to breast carcinoma with adjuvant intravitreal injection of bevacizumab

Cited by 21 publications

References 5 publications

Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series

Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series

Management of choroidal metastases

Uveal metastatic disease: Current and new treatment options (Review)

Contact Info

Product

Resources

About