Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis

Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility

“…The role of vitamin D in the development and progression of endometriosis has also been extensively investigated in animal models. Abbas et al (29) reported the regression of endometriotic implants treated with vitamin D3 in a rat model (29). Recently, Yildirim et al (30) demonstrated the regression of endometriosis in rats treated with vitamin D, as well as associated changes in vascular endothelial growth factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-2 expression levels (29).…”

Cholecalciferol (vitamin D3) prevents postoperative adhesion formation by inactivating the nuclear factor kappa B pathway: a randomized experimental study

“…In addition, the association between vitamin D and endometriosis has been investigated in previous studies [25e27]. As a medical treatment, vitamin D is effective for an endometriosis animal model by acting as an immunemodulatory agent [26,27].…”

“…The dose and time intervals of treatment were adjusted according to a study by Abbas et al [26], and the dose was reported to be 1/1000 of the lethal dose (LD) 50 for rats. We preferred to use corn oil as a vehicle because corn oil extends the potency of vitamin D [36].…”

Assessment of the Possible Role of Vitamin D Defificiency with the Relevant Mechanisms in Gynecological Disorders

“…64 Hayvan çalışmaları ise vitamin D uygulaması-nın endometriyotik odaklar üzerinde olumlu etkileri olabileceğine işaret etmiştir. [74][75][76] İlk olarak Mariani ve ark. (2012), valide edilmiş endometriozis fare modeliyle yaptıkları bir çalışmada VDR agonisti elokalsitolün lezyonların gelişmesini engellediği, implantasyon ve transfer olan endometriyal dokuların organizasyonu üzerinde koruyucu etkilerinin bulunduğunu bildirmişlerdir.…”