1995
DOI: 10.1016/0378-5122(94)00867-7
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Regression of endometrial thickness in combination with reduced withdrawal bleeding as a progestational effect of tibolone in postmenopausal women on oestrogen replacment therapy

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Cited by 26 publications
(4 citation statements)
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“…These findings were associated with a higher rate of continuation than has been reported with other ccEPT regimens 13,15,30,37 . The ultra-low-dose regimens are also consistent with the advice from regulatory authorities to use the lowest effective dose.…”
Section: Discussioncontrasting
confidence: 76%
“…These findings were associated with a higher rate of continuation than has been reported with other ccEPT regimens 13,15,30,37 . The ultra-low-dose regimens are also consistent with the advice from regulatory authorities to use the lowest effective dose.…”
Section: Discussioncontrasting
confidence: 76%
“…Tibolon wurde aus diesem Grund auch bereits als Gestagen zur Induktion einer endometrialen Regression bei ultrasonographisch hoch aufgebautem Endometrium eingesetzt [40]. Tibolon kann diese Regression im Vergleich zu Medroxyprogesteronazetat oder Norethisteron sehr häufig sogar ohne entsprechende vaginale Blutungsauslösung bewirken.…”
Section: Blutungsfreie Therapiemöglichkeitenunclassified
“…Its 3-hydroxymetabolites bind and activate estrogen receptors in bone and vagina, and these metabolites are responsible for relieving climacteric symptoms (Kenemans 2004). On the other hand, the -4 isomer exerts progestogenic and androgenic effects on endometrium, preventing the estrogenic stimulation of this tissue (Meuwissen et al 1995). Tissue specificity of tibolone is established mainly by steroid metabolism, which determines ligand availability for the receptor (Reed and Kloosterboer 2004).…”
Section: General Pharmacologymentioning
confidence: 99%