Regression of Hepatocellular Carcinoma Lung Metastases after Guyabano Fruit Extract Consumption

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of worldwide cancer-related mortality, and even with established treatment paradigms, its global burden demands greater research into therapeutic options. In the following case report, a patient suffering from HCC with lung metastasis demonstrated regression of metastatic disease while consuming guyabano fruit extract in the absence of conventional chemotherapy. While the antineoplastic effects of the guyabano fruit is well documented, there is sparse clinical documentation of HCC regression associated with it, and a better understanding of guyabano and its antineoplastic activity may trigger discovery of novel therapeutic options for this deadly disease.

Antitumoral potential, antioxidant activity and carotenoid content of two Southern Italy tomato cultivars extracts: San Marzano and Corbarino

“…There is a great number of studies emphasizing the importance of a proper nutrition, especially rich in fruits and vegetables, not only to prevent diseases, including cancer, but also as a support to therapies (Gunasekaran, Emmadi, Landers, & Gaba, ; Vidali et al, ). In this context, our study suggests that the possible use of different species of tomatoes, selected based on their biochemical features, should be further evaluated to exploit their antitumoral potential according to the different stages of cancer development and progression.…”

Proposed Biology of the Spontaneous Remission of Hepatocelluar Carcinoma

“…Prolonged case reports of the Spontaneous regression or remission of hepatocellular carcinoma more commonly occur after tumor hypoxia (occlusion of the hepatic artery or portal Vein) [6], hepatitis and liver cirrhosis [1,[7][8][9] liver cirrhosis [2,10,11], hemorrhage [1,12,13], being on dialysis [14][15][16], lung metastases [17][18][19] all have in common a low blood oxygen delivery to the tumor. Occlusion of hepatic artery or the portal vein may result in a reduced or blockage of blood to the tumor, liver cirrhosis may result in macrocytic anemia, hepatitis may result in liver cirrhosis, hemorrhage may result in low blood oxygen transport, dialysis may reduce red blood cell and low kidney function may result in a lower production of erythropoietin thereby a lower red cell count.…”