Regulable Polyelectrolyte‐Surfactant Complex for Antibacterial Biomedical Catheter Coating via a Readily Scalable Route

Abstract

Constructing multifunctional surfaces is one of the practical approaches to address catheter‐related multiple complications but is generally time‐consuming and substrate‐dependent. Herein, a novel anti‐adhesion, antibacterial, low friction, and robustness coating on medical catheters are developed via a universal and readily scalable method based on a regulable polyelectrolyte surfactant complex. The complex is rapidly assembled in one step by electrostatic and hydrophobic interactions between organosilicon quaternary ammonium surfactant (N+Si) and adjustable polyelectrolyte with cross‐linkable, anti‐adhesive, and anionic groups. The alcohol‐soluble feature of the complex is conducive to the rapid formation of coatings on any medical device with arbitrary shapes via dip coating. Different from the conventional polyelectrolyte–surfactant complex coating, the regulated complex coating with nonleaching mode could be stable in harsh conditions (high concentration salt solution, organic reagents, etc.) because of the cross‐linked structure while improving the biocompatibility and reducing the adhesion of various bacteria, proteins, and blood cells. The coated catheter exhibits good antibacterial infection in vitro and in vivo, owing to the synergistic effect of N+Si and zwitterionic groups. Therefore, the rationally designed complex supplies a facile coating approach for the potential development in combating multiple complications of the medical catheter.

Water‐Triggered Segment Orientation of Long‐Lasting Anti‐Biofouling Polyurethane Coatings on Biomedical Catheters via Solvent Exchange Strategy

“…Anti-Biofilm under Solution Flow Condition: According to the description of the method in the past literature, [33] bare TPU catheters and SUPU3 SE, SUPU3 Dry coated TPU catheters with an outer diameter of 2 mm were soaked in S. aureus suspension for 2 h (10 8 CFU mL −1 in PBS buffer), sam-ples were washed with PBS solution three times. Subsequently, catheters were connected to the peristaltic pump, respectively, after which fresh LB was injected into tubes and then incubated at 37 °C for 48 h with a flow rate of 0.5 mL min −1 .…”

Association of oppositely charged polyelectrolyte and surfactant in solution: equilibrium and nonequilibrium features

“…Complexes obtained by combining oppositely charged polyelectrolytes and surfactants are probably among the most studied supramolecular association nanoassemblies due to their broad range of applications in different fields of technological and industrial relevance, including cosmetic, food science, painting, tertiary oil recovery, or drug delivery [14][15][16][17][18][19][20]. The broad spectrum of application of application of this type of colloidal systems has fostered an extensive research activity trying to understand the physico-chemical bases governing the association process, and how this association process can be tuned for optimizing the composition and properties of the mixtures for specific applications [21,22].…”

Hyperbranched Poly‐L‐Lysine‐Based Water‐Insoluble Complexes as Antibacterial Agents with Efficient Antibacterial Activity And Cytocompatibility

“…Fortunately, the idea of polyelectrolyte‐surfactant complexes inspires us to prevent the loss of antibacterial function. [ 28–31 ]…”