Regulação do metabolismo de glicose e ácido graxo no músculo esquelético durante exercício físico

Silveira, Leonardo R.; Pinheiro, Carlos Hermano da Justa; Zoppi, Cláudio C.; Hirabara, Sandro Massao; Vitzel, Kaio Fernando; Bassit, R A; Barbosa, Marina Rodrigues; Sampaio, Igor H.; Melo, Iracema H. P.; Fiamoncini, Jarlei; Carneiro, Everardo M.; Curi, Rui

doi:10.1590/s0004-27302011000500002

Cited by 17 publications

(15 citation statements)

References 41 publications

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“…In addition, a study in mice with high muscle expression of SOD revealed that these animals exhibited a higher rate of glucose uptake during muscle contraction compared to the control group (Schrauwen et al 2003). These results support the proposition that ROS significantly affect the regulation of glucose metabolism during intense muscular activity (Silveira et al 2011).…”

Section: Discussionsupporting

confidence: 72%

Oxidative metabolism and muscle biochemical profile of polo horses supplemented with an ADE vitamin complex

et al. 2013

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Pesq. Vet. Bras. 33(Supl.1):58-62, dezembro 2013 58 RESUMO.-[Metabolismo oxidativo e perfil bioquími-co muscular de cavalos de pólo suplementados com complexo vitamínico ADE.] O jogo de pólo se caracteriza por mudanças abruptas e frequentes na intensidade do exercício dos cavalos. Para satisfazer esta demanda inconstante de energia, os animais utilizam as vias aeróbia e anaeróbia em proporções e intensidade variáveis. Neste contexto deve haver equilíbrio entre a formação das espé-cies reativas de oxigênio (EROs) e a ação das substâncias antioxidantes a fim de evitar o estresse oxidativo e suas consequências. Avaliou-se o efeito da suplementação com vitaminas ADE no metabolismo oxidativo destes animais. Para tanto, 18 equinos mestiços foram distribuídos aleatoriamente em dois grupos: tratado e controle (GT) e controle (GC).Os animais do GT receberam complexo vitamínico ADE (1 mL/50 kg de peso vivo) pela via intramuscular Horses used for the game of polo experience abrupt and frequent changes in exercise intensity. To meet this variable energy demand, the horses use both aerobic and anaerobic pathways in varying proportions and intensities. In this context, there must be a balance between the formation of reactive oxygen species (ROS) and the action of antioxidants to prevent oxidative stress and its consequences. The effect of supplementation with an ADE vitamin complex on oxidative metabolism was evaluated in 18 crossbred horses randomly divided between a treated group (TG) and a control group (CG). The TG animals received the ADE vitamin complex (1mL/50 kg of body weight) by deep intramuscular injection at 30 and 15 days before the game. The CG horses received 10ml of saline by the same administration route and schedule. During the polo match, the animals played for a total of 7.5 min. Blood samples were collected on the same days as the treatments were administered, and immediately before and at 15, 90 and 180 minutes after the game. The concentrations of creatine phosphokinase (CK), lactate dehydrogenase (LDH), lactate, glucose, aspartate aminotransferase (AST), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in the blood samples. After the game, the TG demonstrated higher levels of AST, lactate and glucose than the CG, suggesting more efficient energy use by the treated animals. The higher GSH and lower lactate levels in the TG before the game suggest the presence of a greater antioxidant supply in the treated animals. The maintenance of the MDA levels indicates that neither of the groups exhibited oxidative stress.

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Section: Discussionsupporting

confidence: 72%

Oxidative metabolism and muscle biochemical profile of polo horses supplemented with an ADE vitamin complex

et al. 2013

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“…During moderate exercise maintained for a long period, fatty acids are mobilized from adipose tissue (peripheral and intramuscular) through lipolysis and are used by skeletal muscle. In contrast, during high-intensity exercise, The release of fatty acids from adipose tissue is markedly decreased, followed by an increase in glucose availability and oxidation [59]. In group 6, The horse breed studied is The racing line of The Quarter Horse, a breed used for shorter distance races, which are classified as high-intensity exercise.…”

Section: Gene-biological Process Networkmentioning

confidence: 99%

Identification and Functional Annotation of Genes Related to Horses’ Performance: From GWAS to Post-GWAS

Littiere

Castro

Rodriguez

et al. 2020

Animals

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Integration of genomic data with gene network analysis can be a relevant strategy for unraveling genetic mechanisms. It can be used to explore shared biological processes between genes, as well as highlighting transcription factors (TFs) related to phenotypes of interest. Unlike other species, gene–TF network analyses have not yet been well applied to horse traits. We aimed to (1) identify candidate genes associated with horse performance via systematic review, and (2) build biological processes and gene–TF networks from the identified genes aiming to highlight the most candidate genes for horse performance. Our systematic review considered peer-reviewed articles using 20 combinations of keywords. Nine articles were selected and placed into groups for functional analysis via gene networks. A total of 669 candidate genes were identified. From that, gene networks of biological processes from each group were constructed, highlighting processes associated with horse performance (e.g., regulation of systemic arterial blood pressure by vasopressin and regulation of actin polymerization and depolymerization). Transcription factors associated with candidate genes were also identified. Based on their biological processes and evidence from the literature, we identified the main TFs related to horse performance traits, which allowed us to construct a gene–TF network highlighting TFs and the most candidate genes for horse performance.

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“…Favaro e Vidotti (2010) analisaram a resposta glicêmica durante uma sessão de RPM® em praticantes de ciclismo indoor do gênero feminino, e verificaram que houve uma diminuição do valor glicêmico após o primeiro estímulo de alta intensidade, no qual se aproxima do protocolo e resultados utilizados neste estudo. Silveira et al (2011) explica que em exercícios de alta intensidade há uma maior degradação de glicose, sendo este aumento de sete a 20 vezes mais em comparação aos níveis de repouso (AFONSO et al, 2003) v.3, n.17, p.456-462, 2009.…”

Section: Instrumentos E Procedimentosunclassified

Treinamento Intervalado De Alta Intensidade – HIIT e respostas glicêmicas agudas entre homens saudáveis

Ribeiro

Cabral

Barros

et al. 2020

BJD

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Vários estudos têm abordado as características do Treinamento Intervalado de Alta Intensidade-HIIT na busca de incrementar o treino de indivíduos que normalmente apresentam pouco tempo para realizar sua sessão, e apresenta de forma predominante a capacidade anaeróbia, visto que o mesmo utiliza 90% ou mais da capacidade cardiorrespiratória do indivíduo. Desta forma, entre os benefícios deste treinamento está a prevenção de doenças relacionadas à Síndrome Metabólica. Assim, o objetivo do estudo é comparar as respostas glicêmicas entre homens saudáveis de 18 a 25 anos submetidas ao Treinamento de HIIT realizado entre a bicicleta e a esteira. A amostra foi composta por homens jovens saudáveis, e no dia da coleta de dados, todos os voluntários receberam uma dose de Maltodextrina a trinta minutos antes do início do teste, que foi realizado de forma randomizada através da Esteira e Bicicleta Estacionária. Para controle da intensidade, foi adotada a Escala de Borg com utilização da PSE e a Frequência Cardíaca. Para análise da curva glicêmica, foi utilizado quatro coletas ao longo do protocolo que utilizou o método Tabata®. Dentre os principais resultados, destacamos que o protocolo realizado na Esteira e na Bicicleta Estacionária, os resultados foram similares. Concluímos desta forma, que a utilização do método de treinamento através do HIIT é satisfatória para o controle glicêmico no indivíduo.

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Regulação do metabolismo de glicose e ácido graxo no músculo esquelético durante exercício físico

Cited by 17 publications

References 41 publications

Oxidative metabolism and muscle biochemical profile of polo horses supplemented with an ADE vitamin complex

Oxidative metabolism and muscle biochemical profile of polo horses supplemented with an ADE vitamin complex

Identification and Functional Annotation of Genes Related to Horses’ Performance: From GWAS to Post-GWAS

Treinamento Intervalado De Alta Intensidade – HIIT e respostas glicêmicas agudas entre homens saudáveis

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