Regularities and Mechanisms of Radiation Effects on Cancer Stem Cells In Vitro and In Vivo

Замулаева, И. А.; Matchuk, Olga N.; Selivanova, E. I.; Макаренко, С. А.; Andreev, Vyacheslav; Каприн, А. Д.

doi:10.1007/978-3-319-48838-7_34

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the development of hadron therapy the research into the sensitivity of TSC to the influence of neutron radiation, in particular the neutron flux, is considered of great interest. The experimental data for the first time prove high efficiency of application of neutrons in radiotherapy in respect to TSC elimination [1].…”

Section: Introductionmentioning

confidence: 69%

Response of Resistant Malignant Tumors to Neutron Therapy

Мусабаева

Lisin²

2015

AMR

View full text Add to dashboard Cite

Tumor response to 6.3 MeV fast neutrons generated by U-120 cyclotron was assessed. The study included: 26 patients with locally advanced breast cancer, who received neutron therapy in the regimen of high-dose daily fractions, followed by surgery; 41patients with head and neck cancer and 44 patients with musculoskeletal system cancer. The devised method of 6.3 MeV neutron therapy given in high-dose fractionation regimen resulted in complete tumor response compared to the standard photon therapy.

show abstract

Section: Introductionmentioning

confidence: 69%

Response of Resistant Malignant Tumors to Neutron Therapy

Мусабаева

Lisin²

2015

AMR

View full text Add to dashboard Cite

show abstract

“…Importantly, the number of CD44+ cells in tumors of most of the LCa patients tested profoundly increased upon fractionated irradiation at a total dose of 10 Gy, indicating their potential for resistance to radiotherapy [38]. Its expression was also demonstrated to significantly associate with response to radiotherapy in early stage LCa patients both at the mRNA and protein levels [39].…”

Section: Cd44mentioning

confidence: 96%

Current cancer stem cell biomarkers in laryngeal cancer

Karataş¹,

Barlak²,

Şahin³

2017

The European Research Journal

View full text Add to dashboard Cite

Larynx cancer (LCa), being an aggressive malignancy, is the second most commonly diagnosed malignant type of head and neck squamous cell carcinoma worldwide. Although there have been significant improvements in the detection and diagnosis of LCa in the last decades, it is still one of the considerable causes of cancer deaths and an urgent need for identification of novel biomarkers with diagnostic and prognostic significance still remains. The cancer stem cells (CSCs) resemble normal stem cells in terms of biological features and are considered to play critical roles in biological aggressiveness of tumors. Accumulating evidences have proven the existence of CSCs in various tumors including LCa and they are considered as driving force for tumor relapse, metastasis, and chemo-radioresistance. Comprehensive identification and characterization of the CSCs is of paramount importance for their further characterization to develop more effective and targeted therapeutic strategies against cancer. Here, we reviewed and summarized the most current literature to provide an insight into the functions and roles of current CSCs biomarkers in human LCa. We believe that this review will contribute to the knowledge of scientists especially working with LCa CSCs and will help understanding the significance of CSCs biomarkers implicated in LCa pathogenesis.

show abstract

Regularities and Mechanisms of Radiation Effects on Cancer Stem Cells In Vitro and In Vivo

Cited by 2 publications

References 9 publications

Response of Resistant Malignant Tumors to Neutron Therapy

Response of Resistant Malignant Tumors to Neutron Therapy

Current cancer stem cell biomarkers in laryngeal cancer

Contact Info

Product

Resources

About