The materials of the article contain an integral assessment of the level of development of e-business on the example of the regions of the Volga Federal District (VFD). As a result of calculating the private and local ranks of the values of the selected criteria, fourteen polygons of the level of e-business development were built by the number of regions in the district. The results obtained make it possible to ascertain the existence of a high degree of heterogeneity of the VFD regions in terms of the level of e-business development. The leading regions include the Republic of Tatarstan, the Perm Territory, and the Nizhny Novgorod Region. The outsider regions - the Republic of Mari El, the Republic of Mordovia and the Kirov region - are characterized by a low share of organizations that used the capabilities of the Intranet and Extranet in their activities, the lack of special software tools for managing sales of goods (works, services), limited use of software, in particular, ERP-, CRM and SCM-systems.