The prime purpose for the image reconstruction of a multi-frame superresolution is to reconstruct a higher-resolution image through incorporating the knowledge obtained from a series of relevant low-resolution images, which is useful in numerous fields. Nevertheless, super-resolution image reconstruction methods are usually damaged by undesirable restorative artifacts, which include blurring distortion, noises, and stair-casing effects. Consequently, it is always challenging to achieve balancing between image smoothness and preservation of the edges inside the image. In this research work, we seek to increase the effectiveness of multi-frame super-resolution image reconstruction by increasing the visual information and improving the automated machine perception, which improves human analysis and interpretation processes. Accordingly, we propose a new approach to the image reconstruction of multi-frame super-resolution, so that it is created through the use of the regularization framework. In the proposed approach, the bilateral edge preserving and bilateral total variation regularizations are employed to approximate a high-resolution image generated from a sequence of corresponding images with low-resolution to protect significant features of an image, including sharp image edges and texture details while preventing artifacts. The experimental results of the synthesized image demonstrate that the new proposed approach has improved efficacy both visually and numerically more than other approaches.