Regulated and emerging disinfection by-products in recycled waters

Alexandrou, Lydon D.; Meehan, Barry; Jones, Oliver A.H.

doi:10.1016/j.scitotenv.2018.04.391

Cited by 65 publications

(12 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disinfection byproducts (DBPs) are widespread water contaminants formed when oxidizing disinfectants react with organic matter in raw water . More than 700 DBPs have been identified to date, among which haloacetic acids (HAAs) are the leading species of nonvolatile DBPs . Exposure to HAAs occurs mainly through ingestion of water.…”

Section: Introductionmentioning

confidence: 99%

Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population

Chen

Liu

et al. 2022

Environ. Sci. Technol.

View full text Add to dashboard Cite

Exposure to trichloroacetic acid (TCAA) has been associated with impaired semen quality; however, its association with spermatozoa apoptosis and DNA damage remains unclear. We, therefore, collected single semen and repeated urine samples from male partners of couples attending a reproductive center, which were measured for spermatozoa apoptosis and DNA damage parameters and TCAA concentrations, respectively. Multivariable linear regression models were used to explore the associations between urinary TCAA concentrations and spermatozoa apoptosis (n = 462) and DNA damage parameters (n = 512). After adjusting for potential confounders, positive dose–response relationships were found between urinary TCAA concentrations and percentage of tail DNA (tail%) and tail-distributed moment (TDM) (both p for trend <0.10). Compared with men in the lowest tertile of urinary TCAA concentrations, men in the highest tertile had a greater tail% and TDM of 6.2% (95% CI: 0.7, 12.2%) and 8.9% (95% CI: −1.9, 20.5%), respectively. Urinary TCAA concentrations were unrelated to spermatozoa apoptosis parameters in a dose–response manner. However, urinary TCAA concentrations were positively associated with the percentage of Annexin V+/PI– spermatozoa (apoptotic cells), when urinary TCAA concentrations were modeled as continuous variables. Our results suggest that exposure to TCAA at concentrations in real-world scenarios may be associated with spermatozoa apoptosis and DNA damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population

Chen

Liu

et al. 2022

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…DBPs are formed when chlorine interacts with natural organic materials found in water. Primary sources of DBPs mainly come from chlorinated drinking water and recreational water bodies (65,66). DBPs showed the possibility of cytotoxicity, mutagenicity, teratogenicity, and carcinogenicity (67).…”

Section: Discussionmentioning

confidence: 99%

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

Wei

Chen

Yang

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundVolatile organic compounds (VOCs) are a large group of chemicals widely used in people's daily routines. Increasing evidence revealed the VOCs' accumulating toxicity. However, the VOCs toxicity in male prostate has not been reported previously. Thus, we comprehensively evaluated the association between VOCs and prostate-specific antigen (PSA).MethodsA total of 2016 subjects were included in our study from the National Health and Nutrition Examination Survey with VOCs, PSA, and other variables among U.S. average population. We constructed XGBoost Algorithm Model, Regression Model, and Generalized linear Model (GAM) to analyze the potential association. Stratified analysis was used to identify high-risk populations.ResultsXGBoost Algorithm model identified blood chloroform as the most critical variable in the PSA concentration. Regression analysis suggested that blood chloroform was a positive association with PSA, which showed that environmental chloroform exposure is an independent risk factor that may cause prostate gland changes [β, (95% CI), P = 0.007, (0.003, 0.011), 0.00019]. GAM observed the linear relationship between blood chloroform and PSA concentration. Meanwhile, blood chloroform linear correlated with water chloroform in the lower dose range, indicating that the absorption of water may be the primary origin of chloroform. Stratified associations analysis identified the high-risk group on the chloroform exposures.ConclusionThis study revealed that blood chloroform was positively and independently associated with total PSA level, suggesting that long-term environmental chloroform exposure may cause changes in the prostate gland.

show abstract

“…However, the specific relationship between water purification byproducts and human health remains unclear. Chlorine or chlorine dioxide is typically used as the primary disinfectant of drinking water disinfection with monochloramine as a residual disinfectant [1]. Chlorinated disinfection byproducts (CDBPs) of disinfection can form from substitution, addition, and oxidation reactions between chemical disinfectants and naturally occurring organic matter in the water.…”

Section: Introductionmentioning

confidence: 99%

Health Effect of N-Nitroso Diethylamine in Treated Water on Gut Microbiota Using a Simulated Human Intestinal Microbiota System

Wang

Jiang

et al. 2022

Processes

View full text Add to dashboard Cite

Chlorination disinfection byproducts (CDBPs) can exert adverse human health effects. Many toxicology-based studies confirmed the health hazards of CDBPs, but little research has been done on gut microbiome. We explored the effect of CDBPs on intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). The results showed that CDBPs slightly inhibited the production of short-chain fatty acids, and the abundance of Actinobacteria decreased in the transverse colon and descending colon. The abundance of Proteobacteria increased in the ascending colon and descending colon, while it decreased in the transverse colon. The abundance of Firmicutes decreased in both the ascending colon and descending colon. In particular, the abundance of Lachnospiraceae members, Bilophila, Oscillospira, Parabacteroides, Desulfovibrio, and Roseburia increased in the ascending colon, while the abundance of Sutterella, Bacteroides, Escherichia, Phascolarctobacterium, Clostridium, Citrobacter, and Klebsiella increased in the descending colon. The Shannon index differed significantly in both the ascending colon and descending colon before and after exposure. Overall, we demonstrate the feasibility of applying the SHIME model to studying the effects of intestinal toxicity on health of chlorinated by-products. The findings of this study improve our understanding of the health impact of CDBPs on the intestinal microbiota and better control of CDBPs in treated water is recommended.

show abstract

Regulated and emerging disinfection by-products in recycled waters

Cited by 65 publications

References 101 publications

Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population

Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

Health Effect of N-Nitroso Diethylamine in Treated Water on Gut Microbiota Using a Simulated Human Intestinal Microbiota System

Contact Info

Product

Resources

About