Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli

Dave, Richa K.; Dinger, Marcel E.; Andrew, Megan; Askarian-Amiri, Marjan; Hume, David; Kellie, Stuart

doi:10.1371/journal.pone.0068306

Cited by 37 publications

(30 citation statements)

References 81 publications

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“…35,No. 9 (RNA-Seq) have now demonstrated differential lncRNA expression following activation of monocytes, macrophages, dendritic cells, and fibroblasts, as well as following viral infection in mouse lungs [15,25,26,28,[33][34][35] ( Table 1). As outlined in the following sections, investigators have then examined the role of individual lncRNAs in the innate immune response.…”

Section: Keymentioning

confidence: 99%

Long non-coding RNAs in the regulation of the immune response

Heward

Lindsay

2014

Trends in Immunology

365

316

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It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.

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Section: Keymentioning

confidence: 99%

Long non-coding RNAs in the regulation of the immune response

Heward

Lindsay

2014

Trends in Immunology

365

316

View full text Add to dashboard Cite

show abstract

“…Many identified lncRNAs, including lncRNA-Nfkb2 and lncRNA-Rel, were located near protein-coding regions of immune response genes and contained binding sites for the transcription factors NF-kB (p65), IRF3, Jun-B, or c-Jun [112]. Analyses of LPS-stimulated mouse BMDMs identified the highly up-regulated Ptprj-as1 lncRNA, which is transcribed as AS to Ptprj [114], a type III receptor protein tyrosine phosphatase that regulates monocyte activation by modulating Src kinases [115,116]. Ptprj-as1 is located close to putative transcription factor-binding sites, suggesting that it could play an important role in regulating monocyte activation and responsiveness to LPS.…”

Section: Tlr4 Signalingmentioning

confidence: 99%

Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity

Murphy

Medvedev

2016

Journal of Leukocyte Biology

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Sensing of microbial pathogens and endogenous "alarmins" by macrophages and dendritic cells is reliant on pattern recognition receptors, including membrane-associated TLRs, cytosolic nucleotide-binding and oligomerization domain leucine-rich repeat-containing receptors, retinoic acid-inducible gene I-like receptors, and absent in melanoma 2-like receptors. Engagement of TLRs elicits signaling pathways that activate inflammatory genes whose expression is regulated by chromatin-modifying complexes and transcription factors. Long noncoding RNAs have emerged as new regulators of inflammatory mediators in the immune system. They are expressed in macrophages, dendritic cells, neutrophils, NK cells, and T- and B-lymphocytes and are involved in immune cell differentiation and activation. Long noncoding RNAs act via repression or activation of transcription factors, modulation of stability of mRNA and microRNA, regulation of ribosome entry and translation of mRNAs, and controlling components of the epigenetic machinery. In this review, we focus on recent advances in deciphering the mechanisms by which long noncoding RNAs regulate TLR-driven responses in macrophages and dendritic cells and discuss the involvement of long noncoding RNAs in endotoxin tolerance, autoimmune, and inflammatory diseases. The dissection of the role of long noncoding RNAs will improve our understanding of the mechanisms of regulation of inflammation and may provide new targets for therapeutic intervention.

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“…The relationships between miR‐155 and the above three factors have been widely reported in cancer cells and immune cells [Kutty et al, ; Peyrou et al, ; Wan et al, ]. So the interaction of PTPRJ and miR‐155 might imply an involvement of PTPRJ in immune system; indeed, several reports have demonstrated that PTPRJ functioned in inflammatory responses [Dave et al, ,; Jablonski et al, ]. It is worth exploring the regulatory mechanisms of PTPRJ to NRF/PPAR/STAT3 signaling and investigating the action of miR‐155 in these axes.…”

Section: Discussionmentioning

confidence: 99%

Tumor Suppressor PTPRJ Is a Target of miR‐155 in Colorectal Cancer

Zhang

et al. 2017

J of Cellular Biochemistry

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PTPRJ is known for its antiproliferative role. Loss of heterozygosity (LOH) of PTPRJ has frequently been observed in various human cancers including colorectal cancer (CRC), lung cancer, and breast cancer. However, the function and mechanism of PTPRJ in CRC are not well understood. At the present study, we show that ectopic expression of PTPRJ inhibits cell growth, migration, and invasiveness in CRC cell line HCT116. Moreover, PTPRJ inhibits the tumorigenecity of HCT116 in a xenograft tumor model. MiR-155, the well-known oncomiR in CRC, is identified as an upstream factor of PTPRJ. MiR-155 directly binds to the 3' untranslated region of PTPRJ mRNA and suppresses the mRNA and protein levels of PTPRJ. Furthermore, the growth-promoting and AKT signaling activation effect of miR-155 was abrogated by PTPRJ overexpression, and vice versa. Our study reveals the crucial role of miR-155/PTPRJ/AKT axis in proliferation and migration of CRC cells and suggests a therapeutic potential of PTPRJ. J. Cell. Biochem. 118: 3391-3400, 2017. © 2017 Wiley Periodicals, Inc.

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Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli

Cited by 37 publications

References 81 publications

Long non-coding RNAs in the regulation of the immune response

Long non-coding RNAs in the regulation of the immune response

Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity

Tumor Suppressor PTPRJ Is a Target of miR‐155 in Colorectal Cancer

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