Regulating Spatial Localization and Reactivity Biasness of DNAzymes by Metal Ions and Oligonucleotides

Enzymatic Dissociation of DNA-Histone Condensates in an Electrophoretic Setting: Modulating DNA Patterning and Hydrogel Viscoelasticity

“…We showed alteration in DNA patterning and a simultaneous change in viscoelasticity across the gel matrix depending on the amount of trypsin and gel porosity, in addition to the enzymatic dissociation kinetics of the DNA-histone coacervate. We believe this technology can further be explored in devising a surface-patterned gel with tunable viscoeleasticity and heterogeneity with precise micro- and macropatterned platforms for diversified applications. − One can also envision that the spatiotemporally controlled DNA patterning obtained by applying an electric field will also be potentially important not only in the area of dissipative DNA nanotechnology but also in designing different kinds of spatiotemporally distinct dissipative synthetic systems where catalysts/reagents can be distributed in space in a controlled way for pursuing spatially controlled chemistry in a gel matrix. − …”