2018
DOI: 10.1007/s12079-018-0458-2
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Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes

Abstract: Across the years the CCNs have been increasingly implicated in the development of obesity, diabetes and its complications. Evidence for this is currently derived from their dysregulation in key metabolic pathological states in humans, animal and in vitro models, and also pre-clinical effects of their bioactivities. CCN2 is the best studied in this disease process and the other CCNs are yet to be better defined. Key steps where CCNs may play a pathogenic metabolic role include: (i) obesity and insulin resistanc… Show more

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Cited by 20 publications
(16 citation statements)
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References 80 publications
(95 reference statements)
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“…Reduction of dermal fibroblast size not only impairs dermal fibroblast collagen production (Fisher et al, 2016, Quan et al, 2013b, but also promotes collagen fragmentation through upregulation of multiple matrix metalloproteinases (MMPs) (Fisher et al, 2009, Qin et al, 2017, Qin et al, 2014b, Quan et al, 2013a. CCN2, also known as connective tissue growth factor (CTGF), is a second member of the CCN family of proteins (Perbal, 2004, Twigg, 2018. CCN2 is a secreted, cysteine-rich matricellular J o u r n a l P r e -p r o o f protein that exhibits diverse biological activities in vitro such as cell proliferation, adhesion, migration, and extracellular matrix (ECM) production (McLennan et al, 2013, Moussad andBrigstock, 2000).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Reduction of dermal fibroblast size not only impairs dermal fibroblast collagen production (Fisher et al, 2016, Quan et al, 2013b, but also promotes collagen fragmentation through upregulation of multiple matrix metalloproteinases (MMPs) (Fisher et al, 2009, Qin et al, 2017, Qin et al, 2014b, Quan et al, 2013a. CCN2, also known as connective tissue growth factor (CTGF), is a second member of the CCN family of proteins (Perbal, 2004, Twigg, 2018. CCN2 is a secreted, cysteine-rich matricellular J o u r n a l P r e -p r o o f protein that exhibits diverse biological activities in vitro such as cell proliferation, adhesion, migration, and extracellular matrix (ECM) production (McLennan et al, 2013, Moussad andBrigstock, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…CCN2, also known as CTGF, is a second member of the CCN family of proteins ( Perbal, 2004 ; Twigg, 2018 ). CCN2 is a secreted, cysteine-rich matricellular protein that exhibits diverse biological activities in vitro such as cell proliferation, adhesion, migration, and extracellular matrix (ECM) production ( McLennan et al., 2013 ; Moussad and Brigstock, 2000 ).…”
Section: Introductionmentioning
confidence: 99%
“…When the concentrations of its precursors increase, hyperglycemia, impaired utilization of glucose, TPI deficiency, and high MG levels can occur (Ahmed et al, 2003). Excess carbohydrates, such as glucose or fructose, in patients with Parkinson’s disease and type 2 diabetes result in increased MG production, leading to mitochondrial dysfunction (Hipkiss, 2014; Moraru et al, 2018). In the current research, we determined that the long-term administration of D-galactose, which serves as a monosaccharide, can also generate MG accumulation in mice (Figure 5A).…”
Section: Discussionmentioning
confidence: 99%
“…DR has often been described as a purely vascular disorder of the retina where VEGF is the key factor driving microvascular damages from non-proliferative to proliferative DR [130]. Numerous studies described differential expression of CCN2/CTGF gene in response to hyperglycemia and suggested a potentially important role of CCN2/CTGF in the pathogenesis of diabetes, from the initial metabolic insult(s) (e.g., hyperglycemia, obesity, insulin resistance and deficiency), to end-organ complications/failure [131,132]. Because CCN2/CTGF plays a major role in maintaining the ECM and wound healing, a greater emphasis has been placed on its involvement in diabetes-induced ECM remodeling [69,133].…”
Section: Drmentioning
confidence: 99%