Regulation and roles of <scp>RNA</scp> modifications in aging‐related diseases

Jiapaer, Zeyidan; Su, Dingwen; Hua, Lingyang; Lehmann, H. Immo; Gokulnath, Priyanka; Vulugundam, Gururaja; Song, Shannan; Zhang, Lingying; Gong, Yi; Li, Guoping

doi:10.1111/acel.13657

Cited by 32 publications

(13 citation statements)

References 192 publications

(187 reference statements)

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“…MicroRNA is a class of tiny noncoding RNAs with a length of about 18-25 nucleotides, which plays an important role in gene modifications at the transcriptional level (Ko et al, 2020). Studies have indicated that microRNA is associated with many age-related neurodegenerative diseases, including AD and amyotrophic lateral sclerosis (Jiapaer et al, 2022). Moreover, microRNA is also related to the ageing process of NSCs.…”

Section: Nscs Inhibit Ageing Through Regulation Of Micrornamentioning

confidence: 99%

The role of DNA damage in neural stem cells ageing

Zhong,

Wang,

Yang

et al. 2024

Journal Cellular Physiology

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Neural stem cells (NSCs) are pluripotent stem cells with the potential to differentiate into a variety of nerve cells. NSCs are susceptible to both intracellular and extracellular insults, thus causing DNA damage. Extracellular insults include ultraviolet, ionizing radiation, base analogs, modifiers, alkyl agents and others, while intracellular factors include Reactive oxygen species (ROS) radicals produced by mitochondria, mismatches that occur during DNA replication, deamination of bases, loss of bases, and more. When encountered with DNA damage, cells typically employ three coping strategies: DNA repair, damage tolerance, and apoptosis. NSCs, like many other stem cells, have the ability to divide, differentiate, and repair DNA damage to prevent mutations from being passed down to the next generation. However, when DNA damage accumulates over time, it will lead to a series of alterations in the metabolism of cells, which will cause cellular ageing. The ageing and exhaustion of neural stem cell will have serious effects on the body, such as neurodegenerative diseases. The purpose of this review is to examine the processes by which DNA damage leads to NSCs ageing and the mechanisms of DNA repair in NSCs.

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Section: Nscs Inhibit Ageing Through Regulation Of Micrornamentioning

confidence: 99%

The role of DNA damage in neural stem cells ageing

Zhong,

Wang,

Yang

et al. 2024

Journal Cellular Physiology

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“…32 Key RNA modifications pertinent to PDs include N 6 -methylation of adenosine (m 6 A), N 1 -methylation of adenosine (m 1 A), 5-methylcytosine (m 5 C), pseudouridine (5-ribosyl uracil, Ψ), 7-methylguanosine (m 7 G), and adenosine to inosine (A-to-I) editing (Figure 2A). 33 By categorizing RNA and applying distinct treatments, modifications influence its trajectory in processes such as cellular differentiation, embryonic development, and responses to stress. Provided below is a summary of notable RNA modifications and their regulatory components associated with PDs (Table 1).…”

Section: Rna Modification Pathways and Enzymesmentioning

confidence: 99%

RNA modifications in pulmonary diseases

Qian,

Yang,

et al. 2024

MedComm

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Threatening public health, pulmonary disease (PD) encompasses diverse lung injuries like chronic obstructive PD, pulmonary fibrosis, asthma, pulmonary infections due to pathogen invasion, and fatal lung cancer. The crucial involvement of RNA epigenetic modifications in PD pathogenesis is underscored by robust evidence. These modifications not only shape cell fates but also finely modulate the expression of genes linked to disease progression, suggesting their utility as biomarkers and targets for therapeutic strategies. The critical RNA modifications implicated in PDs are summarized in this review, including N6‐methylation of adenosine, N1‐methylation of adenosine, 5‐methylcytosine, pseudouridine (5‐ribosyl uracil), 7‐methylguanosine, and adenosine to inosine editing, along with relevant regulatory mechanisms. By shedding light on the pathology of PDs, these summaries could spur the identification of new biomarkers and therapeutic strategies, ultimately paving the way for early PD diagnosis and treatment innovation.

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“…The common RNA modifications include N 6 methylation of adenosine (m 6 A), N 1 methylation of adenosine (m 1 A), N 7 -methylguanosine (m 7 G), 5-methylcytosine (m 5 C), 2′O-methylation (2′-O-Me or Nm), pseudouridine (5-ribosyl uracil or Ψ) and adenosine to inosine RNA editing (A-to-I editing), etc. ( Figure 1 ) [ 39 ]. Among these RNA modifications, m 6 A is the most abundant form in eukaryotic cells, extensively studied in recent years.…”

Section: Rna Epigenetics Mechanismsmentioning

confidence: 99%

RNA Epigenetics in Chronic Lung Diseases

Wang

Guo²,

Yan³

2022

Genes

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Chronic lung diseases are highly prevalent worldwide and cause significant mortality. Lung cancer is the end stage of many chronic lung diseases. RNA epigenetics can dynamically modulate gene expression and decide cell fate. Recently, studies have confirmed that RNA epigenetics plays a crucial role in the developing of chronic lung diseases. Further exploration of the underlying mechanisms of RNA epigenetics in chronic lung diseases, including lung cancer, may lead to a better understanding of the diseases and promote the development of new biomarkers and therapeutic strategies. This article reviews basic information on RNA modifications, including N6 methylation of adenosine (m6A), N1 methylation of adenosine (m1A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), 2′O-methylation (2′-O-Me or Nm), pseudouridine (5-ribosyl uracil or Ψ), and adenosine to inosine RNA editing (A-to-I editing). We then show how they relate to different types of lung disease. This paper hopes to summarize the mechanisms of RNA modification in chronic lung disease and finds a new way to develop early diagnosis and treatment of chronic lung disease.

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Regulation and roles of RNA modifications in aging‐related diseases

Cited by 32 publications

References 192 publications

The role of DNA damage in neural stem cells ageing

The role of DNA damage in neural stem cells ageing

RNA modifications in pulmonary diseases

RNA Epigenetics in Chronic Lung Diseases

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