Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer

Camuzi, Diego; Amorim, Ísis Salviano Soares de; Pinto, Luís Felipe Ribeiro; Trivilin, Leonardo Oliveira; Mencalha, André Luiz; Lima, Sheila Coelho Soares

doi:10.3390/cells8040300

Cited by 77 publications

(50 citation statements)

References 134 publications

(159 reference statements)

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“…Epigenetic mechanisms that modify genes activity include histone modifications, non-coding RNAs, and DNA methylation. Epigenetic alterations have been associated with hypoxia in cancer and the complex relationship between hypoxia and epigenetic mechanisms have been reviewed elsewhere 46 . Mice engrafted with epithelial lung cancer cells exposed to IH, increased tumour size and invasiveness and hypermethylation of the tumour-promoting Rab3a gene 47 .…”

Section: Epigenetics Obstructive Sleep Apnoea and Cancermentioning

confidence: 99%

Sleep Apnoea and Cancer: Is There a Relationship?

Marín¹,

Vicente²

2021

BRN

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In recent decades, obstructive sleep apnoea (OSA) has come to represent a major public health problem due to its prevalence and its health consequences. Although the association between OSA and cardiovascular morbidity and mortality is well recognized, its role as a promoter for the development and extension of neoplasms is less known. In recent years, intensive research on the subject has been developed. Bench and animal studies demonstrate how sleep fragmentation and intermittent hypoxia, characteristic phenomena of OSA, are capable of inducing tumorigenesis in various organs and cell lines. However, clinical and population-based epidemiological studies are showing certain contradictory results. These topics are reviewed and discussed in this paper.

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Section: Epigenetics Obstructive Sleep Apnoea and Cancermentioning

confidence: 99%

Sleep Apnoea and Cancer: Is There a Relationship?

Marín¹,

Vicente²

2021

BRN

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“…Reduced oxygen can alter chromatin post-translational modifications, both directly via inhibition of oxygendependent enzymes and indirectly through additional mechanisms such as increased expression and/or HIF recruitment to chromatin [8,10,11,[28][29][30][31][32][33].…”

Section: Chromatin and Hypoxiamentioning

confidence: 99%

Gene transcription and chromatin regulation in hypoxia

Batie

Rocha

2020

Biochemical Society Transactions

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Oxygen sensing is an essential feature of metazoan biology and reductions in oxygen availability (hypoxia) have both physiological and pathophysiological implications. Co-ordinated mechanisms have evolved for sensing and responding to hypoxia, which involve diverse biological outputs, with the main aim of restoring oxygen homeostasis. This includes a dynamic gene transcriptional response, the central drivers of which are the hypoxia-inducible factor (HIF) family of transcription factors. HIFs are regulated in an oxygen-dependent manner and while their role in hypoxia is well established, it is apparent that other key players are required for gene expression control in hypoxia. In this review, we highlight the current understanding of the known and potential molecular mechanisms underpinning gene transcriptional responses to hypoxia in mammals, with a focus on oxygen-dependent effects on chromatin structure.

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“…Of note, many hypoxia and epigenetic pathways are interwoven, as epigenetic modifiers may posttranslationally modify hypoxia-responsive genes affecting their stability. In turn, the hypoxia response regulates the expression of the genes involved in epigenetic signaling [161][162][163]. Epigenetic modifications also play an important role in the acquisition of resistance to various therapies [164,165], including adoptive cell therapy [166].…”

Section: Cancer Microevolution-focus On Epigenomic Alterationsmentioning

confidence: 99%

Dynamic Signatures of the Epigenome: Friend or Foe?

Machnik

Oleksiewicz

2020

Cells

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Highly dynamic epigenetic signaling is influenced mainly by (micro)environmental stimuli and genetic factors. The exact mechanisms affecting particular epigenomic patterns differ dependently on the context. In the current review, we focus on the causes and effects of the dynamic signatures of the human epigenome as evaluated with the high-throughput profiling data and single-gene approaches. We will discuss three different aspects of phenotypic outcomes occurring as a consequence of epigenetics interplaying with genotype and environment. The first issue is related to the cases of environmental impacts on epigenetic profile, and its adverse and advantageous effects related to human health and evolutionary adaptation. The next topic will present a model of the interwoven co-evolution of genetic and epigenetic patterns exemplified with transposable elements (TEs) and their epigenetic repressors Krüppel-associated box zinc finger proteins (KRAB–ZNFs). The third aspect concentrates on the mitosis-based microevolution that takes place during carcinogenesis, leading to clonal diversity and expansion of tumor cells. The whole picture of epigenome plasticity and its role in distinct biological processes is still incomplete. However, accumulating data define epigenomic dynamics as an essential co-factor driving adaptation at the cellular and inter-species levels with a benefit or disadvantage to the host.

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Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer

Cited by 77 publications

References 134 publications

Sleep Apnoea and Cancer: Is There a Relationship?

Sleep Apnoea and Cancer: Is There a Relationship?

Gene transcription and chromatin regulation in hypoxia

Dynamic Signatures of the Epigenome: Friend or Foe?

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