Regulation of Adrenergic Receptors

Davies, Albert O.; Lefkowitz, Robert J.

doi:10.1007/978-94-009-5822-7_5

Cited by 15 publications

(12 citation statements)

References 117 publications

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“…However, an age‐related increase of plasma NE levels to compensate for impaired adrenergic mechanisms cannot explain the observed elevated arterial blood pressure in the elderly. Since increased exposure to catecholamines can result in desensitization of adrenergic receptor function, 43 it is perhaps more likely that the age‐related change in adrenergic receptors is secondary to the increase of NE levels.…”

Section: Physiological Implicationsmentioning

confidence: 99%

Sympathochromaffin System Activity in the Elderly

Linares

Halter

1987

J American Geriatrics Society

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Section: Physiological Implicationsmentioning

confidence: 99%

Sympathochromaffin System Activity in the Elderly

Linares

Halter

1987

J American Geriatrics Society

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“…Moreover, endogenous glucocorticoids maintain normal vasomotor tone of small vessels and mineralocorticoids are known to sensitize blood vessels to angiotensin and catecholamines [ 13]. In animals, adrenalectomy alters the number of adrenergic receptors in several tissues [ 14]. In human septic shock, an absolute adrenal insufficiency is rare, but an impaired adrenal function reserve (i.e.…”

Section: Introductionmentioning

confidence: 99%

Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve

Annane¹,

Bellissant²,

Sebille

et al. 1998

Brit J Clinical Pharma

259

169

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Aims To investigate the relationship between adrenal gland function and pressor response to noradrenaline in septic shock. Methods Basal cortisol level, noradrenaline-mean arterial pressure dose-response curve and cortisol response to intravenous corticotrophin bolus were obtained in nine patients fulfilling usual criteria for septic shock and in six normal volunteers. In patients with septic shock, dose-response curve to noradrenaline was determined a second time 60 min after a 50 mg intravenous hydrocortisone bolus. Results As compared with controls, patients with septic shock had increased basal cortisol levels (mean±s.d.: 1564±818 vs 378±104 nmol l −1 , P=0.002, 95%

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“…A possible explanation for this syndrome is β blocker induced receptor upregulation21 and subsequent adrenergic hypersensitivity after drug withdrawal. In classic abrupt β blocker withdrawal, there is a differential rate of decline between receptor density and plasma concentration of the β blocker producing a milieu for adrenergic hyperresponsiveness.…”

Section: Discussionmentioning

confidence: 99%

beta Blockade in congestive heart failure: persistent adverse haemodynamic effects during chronic treatment with subsequent doses

Kukin

Kalman

Mannino

et al. 1997

Heart

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Objective-To determine whether the acute adverse haemodynamic eVects of blockade in patients with congestive heart failure persist during chronic treatment. Design-Sequential haemodynamic evaluation of heart failure patients at baseline and after three months of continuous treatment with the 1 selective antagonist metoprolol. Setting-Cardiac care unit in university hospital. Patients-26 patients with moderate to severe congestive heart failure (New York Heart Association grade II to IV) and background treatment with digoxin, diuretics, and angiotensin converting enzyme inhibitors, and with a left ventricular ejection fraction < 25%. Methods-Baseline variables included a six minute walk, maximum oxygen consumption, and right heart catheterisation. All patients received metoprolol 6.25 mg orally twice daily initially and the dose was gradually increased to a target of 50 mg twice daily. Haemodynamic measurements were repeated after three months of treatment, both before (trough) and after drug readministration. Results-Long term metoprolol had functional, exercise, and haemodynamic benefits. It produced decreases in heart rate, pulmonary capillary wedge pressure, and systemic vascular resistance, and increases in cardiac index, stroke volume index, and stroke work index. However, when full dose metoprolol was readministered during chronic treatment, there was a reduction in cardiac index (from 2.

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Regulation of Adrenergic Receptors

Cited by 15 publications

References 117 publications

Sympathochromaffin System Activity in the Elderly

Sympathochromaffin System Activity in the Elderly

Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve

beta Blockade in congestive heart failure: persistent adverse haemodynamic effects during chronic treatment with subsequent doses

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