Regulation of Angiogenesis Using Nanomaterial Based Formulations: An Emerging Therapeutic Strategy to Manage Multiple Pathological Conditions

Abstract

Angiogenesis is an indispensable biological process, any aberrancy associated with which can lead to pathological manifestations. To manage different pathological conditions associated with abnormal angiogenesis, Nanomaterial based formulations have been tested in in vitro and in vivo models by different groups. The research advancements pertaining to the applications of major candidate nanomaterials for the treatment of pathologies like tumor, cardiovascular diseases, diabetic retinopathy, age related macular degeneration, chronic wounds, impaired osteogenesis and nerve tissue degeneration, have been briefed in this chapter.

A Graphene Oxide-Angiogenin Theranostic Nanoplatform for the Therapeutic Targeting of Angiogenic Processes: The Effect of Copper-Supplemented Medium

“…Nanomaterials have captured attention recently as angiogenesis modulators. For example, gold nanoparticles reduce the viability, migration, and tube formation of endothelial cells [3][4][5] and have been shown to affect the activity of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) [6]. Similarly, silver nanoparticles have been reported to inhibit VEGF-induced cell proliferation, migration, and tube formation.…”