Regulation of aromatase and 5α-reductase by 25-hydroxyvitamin D3, 1α,25-dihydroxyvitamin D3, dexamethasone and progesterone in prostate cancer cells

Lou, Yan-Ru; Murtola, Teemu J.; Tuohimaa, Pentti

doi:10.1016/j.jsbmb.2005.01.024

Cited by 36 publications

(20 citation statements)

References 30 publications

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“…Previous studies have also shown that increase in serum levels of estrogen in the luteal phase can lead to a decrease in phosphorus levels [26]. Furthermore, it has been also reported that estrogens directly or indirectly impact vitamin D signaling pathway [27], and vice versa [28]. Accordingly, our findings provide additional clues as to the cross-talk that exists between estradiol and vitamin D/PTH signaling pathway.…”

Section: Discussionsupporting

confidence: 69%

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Ranjzad

Mahban

Shemirani

et al. 2010

J Assist Reprod Genet

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Purpose The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Methods Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH) 2 D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed.Results The VDR TaqI "CC" genotype was associated with elevated serum levels of LH (p=0.011). There were significant associations between decreased levels of SHBG and both VDR BsmI "GG" (p=0.009) and ADIPOQ BsmI "CC" (p=0.016) genotypes. Furthermore, patients with CaSR Hin1I "TG" genotype showed higher HoMA-IR (p=0.008). All these associations remained significant after Bonferroni correction. In addition, phosphorus correlated negatively with estradiol (r=−0.298, P=0.026) and positively with glucose (r=0.287, P=0.032). Conclusions These data indicated for the first time that it is possible that the VDR and CASR gene variants through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS.

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Section: Discussionsupporting

confidence: 69%

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Ranjzad

Mahban

Shemirani

et al. 2010

J Assist Reprod Genet

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“…One research revealed that 1,25-dihydroxyvitamin D mediates an enzyme known as aromatase which converts androgen derivatives to estrogen in granulosa cells of the ovaries. 16 Therefore, dysfunction in this mechanism affects the menstrual cycle and ovulation by altering the hormone levels mediated. To validate some of these outcomes, researchers have also experimented in treating PCOS patients with vitamin D and calcium supplementation.…”

Section: Vitamin D Deficiency In Pcosmentioning

confidence: 99%

Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

Chauhan

Sahani

Garg

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovary syndrome (PCOS) is enigma faced by young females since the onset of urbanization. As on day, PCOS is the most common endocrine disorder in the women of reproductive age affecting 4-10%. This study done to measure serum vitamin D3 levels of PCOS patients and to identify its association with factors associated with various symptoms and signs in PCOS.Methods: Institutional based prospective observational study conducted on 70 patients of PCOS, both suspected and already diagnosed, attending gynecology OPD of Department of obstetrics and gynecology of NSCB Medical College Jabalpur from 1 March 2015 to 31 August 2016. Diagnosis of PCOS was made by Rotterdam 2003 criteria. A detailed assessment was done and preformed proforma was filled. Serum Vitamin D3 levels were estimated by standard lab technique ‘Liquid Chromatography Tandem Mass Spectrometry’ and categorized into vitamin D3 sufficient >30ng/dl, insufficient 20-29ng/dl and deficient <20ng/dl. Categorical data was coded numerically before the analysis. For comparison of frequency distribution chi square test or fisher’s exact test were applied as appropriate.Results: Prevalence of Vitamin D3 deficiency in patients of PCOS was found to be 84.3%.Conclusions: The present study concludes that there is correlation between vitamin D3 and PCOS, screening and correction of vitamin D3 deficiency may prevent PCOS and its manifestations. Hence, it is speculated that improvement of vitamin D3 levels at a younger age can contribute to prevention of PCOS.

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“…1), were found to be altered by 1,25-dihydroxyvitamin D 3 treatment . Accumulated data have revealed that sex hormone biosynthesis and metabolism may be regulated by vitamin D (Barrera et al, 2007;Krishnan et al, 2010;Lou et al, 2005;Tanaka et al, 1996). Important reactions in the metabolism of androgens and estrogens are catalyzed by 5-reductase and aromatase (CYP19A1) (Fig.…”

Section: Vitamin D 3 Exerts Tissue-specific Effects On Estrogen and Amentioning

confidence: 99%

Tissue-Specific Regulation of Sex Hormone Biosynthesis and Metabolism: Novel Aspects on Hormonal Signalling and Maintenance of Cellular Steroid Levels

Norlin¹,

Wikvall²

2012

Sex Hormones

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Regulation of aromatase and 5α-reductase by 25-hydroxyvitamin D3, 1α,25-dihydroxyvitamin D3, dexamethasone and progesterone in prostate cancer cells

Cited by 36 publications

References 30 publications

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

Tissue-Specific Regulation of Sex Hormone Biosynthesis and Metabolism: Novel Aspects on Hormonal Signalling and Maintenance of Cellular Steroid Levels

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