Regulation of blood viscosity in disease prevention and treatment

Gan, Chunfang; Zhao, Lei; Liu, Yaowen; Liao, Fulong; Han, Dong; Zhou, Hong

doi:10.1007/s11434-012-5165-4

Cited by 42 publications

(21 citation statements)

References 77 publications

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“…Different fluids under clinical conditions have been found to cause different hemorheological effects, which may contribute to the persistence or deterioration of the physiological state [ 7 , 22 ]. The current study was conducted to investigate the influence of synthetic colloids (HES 130, HES 200, and GEL) and LR on plasma viscosity, erythrocyte aggregability, and erythrocyte deformability in vitro and in a rodent model of controlled hemorrhage in vivo .…”

Section: Discussionmentioning

confidence: 99%

Effects of synthetic colloid and crystalloid solutions on hemorheology in vitro and in hemorrhagic shock

Gan

Zhao

et al. 2015

Eur J Med Res

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BackgroundPlasma expanders are commonly used in the management of critically ill patients, which may exhibit altered hemorheology. We evaluated the effects of various synthetic colloids and Lactated Ringer’s (LR) solution on hemorheological parameters in vitro and in a rodent hemorrhagic shock model.MethodsFor the in vitro experiments, rat blood was incubated with hydroxyethyl starch (HES) 130/0.4, HES 200/0.5, succinylated gelatine (GEL), or LR at various ratios. The control consisted of blood without dilution. The hemorheological parameters were measured after a 15-min incubation. For the in vivo study, rats were subjected to a severe volume-controlled hemorrhage and were resuscitated using a colloid solution (HES 130/0.4, HES 200/0.5, or GEL) or LR. The hemorheological parameters were measured 2 h after resuscitation.ResultsThe GEL significantly elevated the plasma viscosity compared to the other groups. In the in vitro study, GEL and LR accelerated the erythrocyte aggregation. There was no significant difference between HES 130/0.4, HES 200/0.5, and control groups regarding the aggregation amplitude and index. In the in vivo study, the aggregation amplitude increased significantly in the GEL group compared to the HES 130/0.4, HES 200/0.5, LR, and sham groups. There was no significant difference between the groups with respect to the elongation index in vivo.ConclusionsHydroxyethyl starch did not change the erythrocyte aggregation compared to the control. GEL significantly accelerates the erythrocyte aggregation and elevates the plasma viscosity compared to hydroxyethyl starch. The in vitro hemorheological measurements most likely provide hints for the in vivo study.

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Section: Discussionmentioning

confidence: 99%

Effects of synthetic colloid and crystalloid solutions on hemorheology in vitro and in hemorrhagic shock

Gan

Zhao

et al. 2015

Eur J Med Res

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“…44 Abnormality in whole blood viscosity can be an early indicator of cardio-or cerebro-vascular diseases, diabetes mellitus, and liver diseases. 45 Furthermore, low RBC count in patients undergoing chemotherapy can indicate chemotherapy-induced anemia. Unlike the conventional test method where RBCs are removed and only plasma is utilized for diagnostics, [46][47][48][49] whole blood can be directly applied onto our nrLFA device since we utilize the transport of RBCs as a color indicator of rheological properties of whole blood, which are related to the individual's blood coagulation condition.…”

Section: 024116-1mentioning

confidence: 99%

Flow reproducibility of whole blood and other bodily fluids in simplified no reaction lateral flow assay devices

Han

Hegener

et al. 2017

Biomicrofluidics

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The "no reaction" lateral flow assay (nrLFA) uses a simplified LFA structure with no conjugate pad and no stored reagents. In the nrLFA, the capillary-based transport time or distance is the key indicator, rather than the outcome of a biochemical reaction. Hence, the calibration and reproducibility of the nrLFA device are critical. The capillary flow properties of several membrane types (nitrocellulose, nylon, cellulose acetate, polyethersulfone, and polyvinylidene difluoride) are evaluated. Flow rate evaluations of MilliporeSigma Hi-Flow™ Plus (HF075, HF135 and HF180) nitrocellulose membranes on nrLFA are performed using bodily fluids (whole blood, blood plasma, and artificial sweat). The results demonstrate that fluids with lower viscosity travel faster, and membranes with slower flow rate exhibit higher capability to distinguish fluids with different viscosities. Reproducibility tests of nrLFA are performed on HF075, demonstrating excellent reproducibility. The coefficient of variation for blood coagulation tests performed with the nrLFA using induced coagulation was 5% for the plasma front and 2% for the RBC front. The effects of variation in blood hematocrit and sample volume are also reported. The overall results indicate that the nrLFA approach has a high potential to be commercially developed as a blood monitoring point-of-care device with simple calibration capability and excellent reproducibility.

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“…Przepływ krwi w naczyniach krwionośnych zależy nie tylko od właściwości fizykochemicznych krwi, ale także od stanu naczyń krwionośnych [4,6,7]. W nowotworach hematologicznych stwierdzono, że chemioterapia, radioterapia oraz przeszczep krwiotwórczych komórek macierzystych przyczyniają się do wzrostu sztywności tętnic [49]. Mechanizmami wpływającymi na podwyższoną sztywność tętnic są stres oksydacyjny, upośledzona homeostaza ściany naczyń, dysfunkcje śródbłonka i apoptoza śródbłonka, nadekspresja cytokin zapalnych, miażdżyca naczyń oraz zwiększona lepkość krwi [53].…”

Section: Profil Hemoreologiczny Pacjentów Z Chorobami Nowotworowymiunclassified

Obraz hemoreologiczny w chorobach nowotworowych

Marcinkowska‐Gapińska

2019

LOS

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StreszczenieHemoreologia jest nauką zajmującą się badaniem przepływu krwi w naczyniach krwionośnych. Parametry reologiczne mają znaczenie w patogenezie wielu chorób, w tym także w chorobach nowotworowych. Determinantami przepływu krwi są wartość hematokrytu, lepkość osocza, lepkość krwi pełnej oraz zdolność erytrocytów do deformacji i agregacji. Zmiany wartości lepkości krwi pełnej, lepkości osocza jak podwyższoną skłonność erytrocytów do agregacji i obniżoną zdolność do deformacji obserwuje się w przypadku wielu zmian nowotworowych. Wielu autorów wskazuje na możliwość wykorzystania badań reologicznych w prognozowaniu stopnia zawansowania choroby jak również wyboru metody terapeutycznej. Postulowane jest również modyfikowanie nadmiernej lepkości jako jednej z koncepcji leczenia chorób nowotworowych. AbstractHemoreology is a branch of science dealing with the study of blood flow in blood vessels. Rheological parameters are important indicators of the pathogenesis in many diseases, including cancer. Blood flow determinants are hematocrit, plasma viscosity, whole blood viscosity, and the ability of erythrocytes to deform and aggregate. Changes in the value of whole blood viscosity, plasma viscosity and other parameters such as increased erythrocyte aggregation tendency and reduced deformability are observed in many neoplastic lesions. Many authors point to the possibility of using rheological tests to predict the degree of disease progression as well as to make a choice of the therapeutic method. It is also postulated that reduction of excessive viscosity could be a good concept for the treatment of cancer.Słowa kluczowe: hemoreologia, lepkość krwi, lepkość osocza, choroby nowotworowe

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Regulation of blood viscosity in disease prevention and treatment

Cited by 42 publications

References 77 publications

Effects of synthetic colloid and crystalloid solutions on hemorheology in vitro and in hemorrhagic shock

Effects of synthetic colloid and crystalloid solutions on hemorheology in vitro and in hemorrhagic shock

Flow reproducibility of whole blood and other bodily fluids in simplified no reaction lateral flow assay devices

Obraz hemoreologiczny w chorobach nowotworowych

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