Regulation of bone formation using rapamycin-induced BMP2 expression system: influence of implanted cell number

Lim, Dong Woo; Park, Bae Keun; Jang, Won Gu; Lee, Kkot Nim; Franceschi, Renny T.; Kim, Sun Hun; Lee, Shee Eun; Koh, Joon

doi:10.1007/s13273-010-0026-1

Cited by 3 publications

(1 citation statement)

References 21 publications

(22 reference statements)

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“…FK506 and rapamycin are immunosuppressants that have been used for reducing the activity of patients’ immune systems after organ transplantations in order to lower the risk of organ rejections [73–75]. Intriguingly, these two small molecules were recently found to be osteoinductive, as evidenced by the ectopic bone formation in subcutaneous sites [76,77]. Phenamil is a derivative of the diuretic amiloride, which has been recently shown to induce osteogenesis of mouse mesenchymal stem cells (MSCs) in vitro [71].…”

Section: Small Molecules With Osteoinductive Potentialmentioning

confidence: 99%

The Role of Small Molecules in Musculoskeletal Regeneration

Ashe

Kan

et al. 2012

Regen. Med.

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The uses of bone morphogenetic proteins and parathyroid hormone therapeutics are fraught with several fundamental problems, such as cost, protein stability, immunogenicity, contamination and supraphysiological dosage. These downsides may effectively limit their more universal use. Therefore, there is a clear need for alternative forms of biofactors to obviate the drawbacks of protein-based inductive factors for bone repair and regeneration. Our group has studied small molecules with the capacity to regulate osteoblast differentiation and mineralization because their inherent physical properties minimize limitations observed in protein growth factors. For instance, in general, small molecule inducers are usually more stable, highly soluble, nonimmunogenic, more affordable and require lower dosages. Small molecules with the ability to induce osteoblastic differentiation may represent the next generation of bone regenerative medicine. This review describes efforts to develop small molecule-based biofactors for induction, paying specific attention to their novel roles in bone regeneration.

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