Regulation of cholecystokinin secretion in humans

Liddle, Rodger A.

doi:10.1007/s005350050328

Cited by 78 publications

(58 citation statements)

References 73 publications

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“…CCK has been associated with delay of gastric emptying, stimulation of gallbladder contraction, increases in pancreatic enzyme secretion, and reduced food intake (Purhonen, 2008). CCK is secreted by I enteroendocrine cells located predominantly in the proximal small intestinal mucosa in response to intraluminal nutrients such as FA and proteins (Liddle, 2000). Relatively little is known concerning the mechanisms whereby nutrients influence CCK synthesis and secretion.…”

Section: Cholecystokinin (Cck) Is a Peptide Hormone Reported To Have mentioning

confidence: 99%

β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake

Maux¹,

Brodkorb²,

Croguennec³

et al. 2013

Journal of Dairy Science

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The dairy protein β-lactoglobulin (BLG) is known to bind fatty acids such as the salt of the essential longchain fatty acid linoleic acid (cis,cis-9,12-octadecadienoic acid, n-6, 18:2). The aim of the current study was to investigate how bovine BLG-linoleate complexes, of various stoichiometry, affect the enzymatic digestion of BLG and the intracellular transport of linoleate into enterocyte-like monolayers. Duodenal and gastric digestions of the complexes indicated that BLG was hydrolyzed more rapidly when complexed with linoleate. Digested as well as undigested BLG-linoleate complexes reduced intracellular linoleate transport as compared with free linoleate. To investigate whether enteroendocrine cells perceive linoleate differently when part of a complex, the ability of linoleate to increase production or secretion of the enteroendocrine satiety hormone, cholecystokinin, was measured. Cholecystokinin mRNA levels were different when linoleate was presented to the cells alone or as part of a protein complex. In conclusion, understanding interactions between linoleate and BLG could help to formulate foods with targeted fatty acid bioaccessibility and, therefore, aid in the development of food matrices with optimal bioactive efficacy

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Section: Cholecystokinin (Cck) Is a Peptide Hormone Reported To Have mentioning

confidence: 99%

β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake

Maux¹,

Brodkorb²,

Croguennec³

et al. 2013

Journal of Dairy Science

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“…Factors such as the presence of an acidic bolus and digested proteins and fats have been demonstrated to cause the release of CCK or secretin from the small-intestinal mucosa in human studies (83) . In particular, strong CCK releases have been noted in response to the presence of luminal fatty acid with a chain length of .…”

Section: Enteroendocrine Systemmentioning

confidence: 99%

Physiological parameters governing the action of pancreatic lipase

et al. 2010

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The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the action of pancreatic lipase under the range of physiological conditions that occur within the human small intestine, and the literature that does exist is often contradictory. Due to the importance of pancreatic lipase activity to nutrition and weight management, the present review aims to assess the current body of knowledge with regards to the physiology behind the action of this unique gastrointestinal enzyme system. Existing data would suggest that pancreatic lipase activity is affected by intestinal pH, the presence of colipase and bile salts, but not by the physiological range of Ca ion concentration (as is commonly assumed). The control of secretion of pancreatic lipase and its associated factors appears to be driven by gastrointestinal luminal content, particularly the presence of acid or digested proteins and fats in the duodenal lumen. Secretion of colipase, bile acids and pancreatic lipase is driven by cholecystokinin and secretin release.

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“…The release of CCK and gastrin is stimulated by the ingestion of a meal and its chemical composition in most singlestomached species (Liddle, 1997(Liddle, , 2000. For example, in human subjects, the basal blood levels of CCK are approximatively 1 pM and increase to 5 -10 pM after a mixed meal (Liddle et al 1985).…”

Section: Factors Regulating Gastrin and Cholecystokinin Releasementioning

confidence: 99%

“…For gastrin, the well-recognised luminal stimuli are amino acids (particularly aromatic amino acids), dietary amines and Ca (Dockray et al 2001). Moreover, intravenous infusion of amino acids stimulates CCK secretion (Liddle, 1997(Liddle, , 2000. In the rat, food restriction induces a reduction of pancreatic function (decrease of amylase secretion) by a mechanism that evidently involves a decrease of CCK release and a down regulation of the CCK receptors (reduction of CCK receptor affinity and capacity) (Chowdhury & Rayford, 2001); these data suggest that CCK plays an important physiological role in adaptation of eating less food and thereby to a lowering of body size in rats and possibly in other mammals.…”

Section: Factors Regulating Gastrin and Cholecystokinin Releasementioning

confidence: 99%

“…There is now strong evidence that a feedback mechanism exists in the chicken, pig, rat, dog and man. The existence and description of at least two types of CCKreleasing factors have been reported (Liddle, 1997(Liddle, , 2000. One of these, LCRF, was isolated from rat intestinal washings, while the other, diazepam-binding inhibitor, was identified in porcine intestine.…”

Section: Factors Regulating Gastrin and Cholecystokinin Releasementioning

confidence: 99%

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Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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Regulation of cholecystokinin secretion in humans

Cited by 78 publications

References 73 publications

β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake

β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake

Physiological parameters governing the action of pancreatic lipase

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

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