Regulation of Complex Formation of POB1/Epsin/Adaptor Protein Complex 2 by Mitotic Phosphorylation

Kariya, Kenji; Koyama, Shin-ya; Nakashima, Satoru; Oshiro, Takafumi; Morinaka, Kenji; Kikuchi, Akira

doi:10.1074/jbc.m000521200

Cited by 58 publications

(72 citation statements)

References 44 publications

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“…The entire PCR products were sequenced, and the structures of all plasmids were confirmed by restriction analyses. pGEX-2T/POB1-(1-125), pGEX-2T/POB1-(126 -227), pGEX-2T/POB1-(228 -406), pGEX-2T/ POB1-(322-521), pGEX-2T/RalBP1-(364 -647), pMAL-c2/RalBP1-(364 -647), pCGN/POB1, pGEX-2T/paxillin ␣, and pBJ-Myc/RalBP1 were constructed as described (2,19,(33)(34)(35)(36).…”

Section: Methodsmentioning

confidence: 99%

Interaction of POB1, a Downstream Molecule of Small G Protein Ral, with PAG2, a Paxillin-binding Protein, Is Involved in Cell Migration

Oshiro

Koyama

Sugiyama

et al. 2002

Journal of Biological Chemistry

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Section: Methodsmentioning

confidence: 99%

Interaction of POB1, a Downstream Molecule of Small G Protein Ral, with PAG2, a Paxillin-binding Protein, Is Involved in Cell Migration

Oshiro

Koyama

Sugiyama

et al. 2002

Journal of Biological Chemistry

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“…In animals, Epsins are phosphorylated during mitosis, resulting in lower affinity toward adaptor proteins Kariya et al, 2000). In plants, to date, there is no evidence for phosphorylation, although it was speculated that At-AP180 is regulated via phosphorylation by a casein kinase because of the presence of four conserved casein kinase substrate sites in its primary sequence (Barth and Holstein, 2004).…”

Section: Posttranslational Regulationmentioning

confidence: 99%

Helping Hands for Budding Prospects: ENTH/ANTH/VHS Accessory Proteins in Endocytosis, Vacuolar Transport, and Secretion

Zouhar

Sauer

2014

The Plant Cell

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Coated vesicles provide a major mechanism for the transport of proteins through the endomembrane system of plants. Transport between the endoplasmic reticulum and the Golgi involves vesicles with COPI and COPII coats, whereas clathrin is the predominant coat in endocytosis and post-Golgi trafficking. Sorting of cargo, coat assembly, budding, and fission are all complex and tightly regulated processes that involve many proteins. The mechanisms and responsible factors are largely conserved in eukaryotes, and increasing organismal complexity tends to be associated with a greater numbers of individual family members. Among the key factors is the class of ENTH/ANTH/VHS domain-containing proteins, which link membrane subdomains, clathrin, and other adapter proteins involved in early steps of clathrin coated vesicle formation. More than 30 Arabidopsis thaliana proteins contain this domain, but their generally low sequence conservation has made functional classification difficult. Reports from the last two years have greatly expanded our knowledge of these proteins and suggest that ENTH/ANTH/VHS domain proteins are involved in various instances of clathrin-related endomembrane trafficking in plants. This review aims to summarize these new findings and discuss the broader context of clathrin-dependent plant vesicular transport.

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“…REPS2/POB1 is a protein partner of RalBP1, contains a single EH domain, two SH3 binding sites and several other functional regions (Ikeda et al, 1998). REPS2/POB1 has been implicated in endocytosis and signal transduction (Ikeda et al, 1998;Nakashima et al, 1999;Kariya et al, 2000) and is currently evaluated for its putative role in prostate cancer progression.…”

Section: Introductionmentioning

confidence: 99%

REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells

et al. 2003

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Regulation of Complex Formation of POB1/Epsin/Adaptor Protein Complex 2 by Mitotic Phosphorylation

Cited by 58 publications

References 44 publications

Interaction of POB1, a Downstream Molecule of Small G Protein Ral, with PAG2, a Paxillin-binding Protein, Is Involved in Cell Migration

Interaction of POB1, a Downstream Molecule of Small G Protein Ral, with PAG2, a Paxillin-binding Protein, Is Involved in Cell Migration

Helping Hands for Budding Prospects: ENTH/ANTH/VHS Accessory Proteins in Endocytosis, Vacuolar Transport, and Secretion

REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells

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