Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals

Khoo, Ai Leng; Chai, Louis Yi Ann; Koenen, Hans J. P. M.; Sweep, Fred C.G.J.; Joosten, Irma; Netea, Mihai G.; Ven, A.J.A.M. van der

doi:10.1111/j.1365-2249.2010.04315.x

Cited by 166 publications

(143 citation statements)

References 43 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…7 As alterações do metabolismo da vitamina D podem modificar a integridade da barreira cutânea e favorecer uma patologia inflamatória e/ ou infeciosa. 7 A vitamina D é capaz de suprimir a resposta inflamatória mediada por TLR (toll like-receptors), diminuir a produção e secreção de citoquinas pelas células mononucleares, 11 nomeadamente, de citoquinas da via Th1 e inibir a proliferação dos linfócitos T. 12 Para além disso, promove a autofagia nos macrófagos humanos ajudando na defesa de infeções oportunistas. 13 Sendo os linfócitos T as principais células do sistema imune adaptativo implicadas na fisiopatologia da psoríase, 3 a sua inibição terá claramente um papel favorável na evolução da patologia.…”

Section: Discussionunclassified

Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

Martins

Bettencourt

Torres

2018

SPDV

View full text Add to dashboard Cite

RESUMO -Introdução:A psoríase é uma dermatose imunomediada caraterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias. É uma doença multifatorial influenciada por alterações genéticas e epigenéticas despoletadas por estímulos ambientais. O clima e a exposição solar parecem afetar a prevalência da psoríase e a radiação ultravioleta é útil na abordagem terapêutica. O nosso objectivo foi avaliar a influência do mês de nascimento (como marcador da época de gestação) no risco de desenvolver psoríase. Métodos: Comparação da distribuição dos meses de nascimentos nos pacientes com psoríase (n = 755) seguidos no Centro Hospitalar e Universitário do Porto com uma população controlo constituída pelos cidadãos portugueses nascidos no mesmo período e área geográfica dos pacientes com psoríase (n = 6 560 032). Resultados: Observou-se uma diminuição do número de nascimentos de pacientes com psoríase no mês de outubro estatisticamente significativa (OR 0,74; 95% CI 0,55 -0,99; p 0,041). Após correção de Bonferroni e após agrupar os meses por trimestres, não se observaram diferenças estatisticamente significativas. Conclusão: As diferenças estatísticas pouco significativas e não significativas apresentadas podem ser explicadas pelas características meteorológicas particulares de Portugal que podem tornar a síntese de vitamina D relativamente estável durante o ano. A perceção da influência ambiental no desenvolvimento de determinada patologia é importante porque permite o estabelecimento de medidas preventivas que conduzirão à diminuição da sua incidência. PALAVRAS-CHAVE -Estações; Factores de Risco; Luz Solar; Psoríase; Raios Ultravioleta; Vitamina D. (OR 0.74; p 0.041 Effect of Month of Birth on the Risk of Developing Psoriasis ABSTRACT -Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis. Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032). Results: Birth rate of psoriasis patients decreased in October INTRODUÇÃOA psoríase é uma dermatose imunomediada caracterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias na derme e epiderme.1,2 Afeta cerca de 2% da população mundial e, assim como outras doenças autoimunes (DAI), resulta da...

show abstract

Section: Discussionunclassified

Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

Martins

Bettencourt

Torres

2018

SPDV

View full text Add to dashboard Cite

show abstract

“…27 In peripheral blood mononuclear cells, vitamin D decreases proinflammatory cytokine release. 28 Vitamin D also inhibits TNFa-and /or IFNg-induced IL-8 and IL-6 production in keratinocytes. 29,30 Thus, in addition to its effect of suppressing POSTN, topical OCT might be effective on local scleroderma by inhibiting inflammatory cytokine expression.…”

Section: Discussionmentioning

confidence: 99%

A vitamin D analog inhibits Th2 cytokine- and TGFβ -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis

Terao

Yang

Matsumura

et al. 2015

Dermato-Endocrinology

View full text Add to dashboard Cite

& Ichiro Katayama (2015) A vitamin D analog inhibits Th2 cytokine-and TGFβ -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis, Dermato-Endocrinology, 7:1, e1010983, DOI: 10.1080DOI: 10. /19381980.2015 Scleroderma is an autoimmune disease characterized by extracellular matrix deposition and inflammation. Topical vitamin D analogs have been reported as effective treatments for scleroderma. We previously reported that a matricellular protein, periostin (POSTN), contributes to pathogenesis of scleroderma as POSTN knockout mice were resistant to bleomycin (BLM)-induced scleroderma. We investigated whether a vitamin D analog affects the expression of POSTN in dermal fibroblasts and in a BLM-induced scleroderma model. The vitamin D analog, maxacalcitol ), was applied to dermal fibroblasts and POSTN expression was measured. The effect of OCT on Th2 cytokine-and TGFb-induced POTSN and Collagen 1 a 1 (Col1A1) expression was also assessed. In vivo, OCT was administered to BLM-induced scleroderma model and outcomes were determined by dermal thickness, collagen density and POSTN expression. Treatment with OCT significantly decreased POSTN expression in dermal fibroblasts. Th2 cytokine-and TGFb-induced expression of POSTN and Col1A1 was also suppressed by OCT. In vivo, OCT administration decreased the density of collagen bundles and POSTN expression in a BLM-induced scleroderma model. In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine-and TGFb-induced POSTN expression.

show abstract

“…Their expression on PBMCs was shown to be seasonally modulated by blood circulating Vitamin D 3 resulting in the secretion of distinct cytokine patterns that contribute to alter the innate immune response [12].…”

Section: Discussionmentioning

confidence: 99%

Seasonal modulation of the C-type lectin MGL on human DCs

Zizzari¹,

Napoletano²,

Rughetti³

et al. 2013

OJI

View full text Add to dashboard Cite

The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Ms), able to bind GalNAc (Tn)-carrying structures. This receptor also recognized Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible application in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL + donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of glucocorticoids, in fact MGL is up-regulated in presence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.

show abstract

Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals

Cited by 166 publications

References 43 publications

Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

A vitamin D analog inhibits Th2 cytokine- and TGFβ -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis

Seasonal modulation of the C-type lectin MGL on human DCs

Contact Info

Product

Resources

About