Regulation of dally, an Integral Membrane Proteoglycan, and Its Function during Adult Sensory Organ Formation of Drosophila

Fujise, Momoko; Izumi, Susumu; Selleck, Scott B.; Nakato, Hiroshi

doi:10.1006/dbio.2001.0290

Cited by 70 publications

(68 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, Fujise et al demonstrated that dally mRNA distribution was virtually identical to that observed with a dally-lacZ line (Fujise et al, 2003). dally expression in the wing pouch is induced by Hh and Wg signaling, but repressed by Dpp signaling (Fujise et al, 2001;Fujise et al, 2003). As shown in Fig.…”

Section: Dlp Forms An Inverse Gradient To the Wg Gradient And Its Expsupporting

confidence: 71%

“…Collectively, our data argue that Dlp expression is negatively regulated by Wg signaling. Taken together with the observation that Dally is upregulated by Wg signaling at DV boundary (Fujise et al, 2001), our new results suggest that the relative contributions of Dally and Dlp in Wg gradient formation are controlled, at least in part, by their expression levels.…”

Section: Dlp Forms An Inverse Gradient To the Wg Gradient And Its Expsupporting

confidence: 71%

See 1 more Smart Citation

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

et al. 2005

View full text Add to dashboard Cite

Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning. The molecular mechanism(s) of Wg gradient formation is not fully understood. Here,we systematically analyzed the roles of glypicans Dally and Dally-like protein(Dlp), the Wg receptors Frizzled (Fz) and Fz2, and the Wg co-receptor Arrow(Arr) in Wg gradient formation in the wing disc. We demonstrate that both Dally and Dlp are essential and have different roles in Wg gradient formation. The specificities of Dally and Dlp in Wg gradient formation are at least partially achieved by their distinct expression patterns. To our surprise,although Fz2 was suggested to play an essential role in Wg gradient formation by ectopic expression studies, removal of Fz2 activity does not alter the extracellular Wg gradient. Interestingly, removal of both Fz and Fz2, or Arr causes enhanced extracellular Wg levels, which is mainly resulted from upregulated Dlp levels. We further show that Notum, a negative regulator of Wg signaling, downregulates Wg signaling mainly by modifying Dally. Last, we demonstrate that Wg movement is impeded by cells mutant for both dally and dlp. Together, these new findings suggest that the Wg morphogen gradient in the wing disc is mainly controlled by combined actions of Dally and Dlp. We propose that Wg establishes its concentration gradient by a restricted diffusion mechanism involving Dally and Dlp in the wing disc.

show abstract

Section: Dlp Forms An Inverse Gradient To the Wg Gradient And Its Expsupporting

confidence: 71%

Section: Dlp Forms An Inverse Gradient To the Wg Gradient And Its Expsupporting

confidence: 71%

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

et al. 2005

View full text Add to dashboard Cite

show abstract

“…It has also been proposed that Dally is required for the stability and long-range distribution of Hh and Wg. dally mRNA expression is strong at the A/P and D/V compartment borders and uniform in the notum (Fujise et al, 2001). A Dally-YFP reporter construct shows a similar expression pattern and most likely reproduces Dally protein distribution in the wing disc (Fig.…”

Section: Both the Egf Repeats And Wd Of Shf And Wif1 Interact With Glmentioning

confidence: 72%

The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog

et al. 2012

View full text Add to dashboard Cite

There was an error published in Development 139, 3849-3858. Fig. 4B incorrectly showed an image of an apGal4>UAS-hWIF1 wing disc instead of an apGal4>NTDm -WD Hs -EGF Dm wing disc. The correct figure is shown below.As both genotypes display a very similar disc phenotype, this error does not change the conclusions of the paper.The authors apologise to readers for this mistake. CORRIGENDUMThe WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog David Sánchez-Hernández, Javier Sierra, João Ramalho Ortigão-Farias and Isabel Guerrero RESEARCH ARTICLE 3849 Development 139, 3849-3858 (2012) INTRODUCTIONSecreted signaling proteins of the Wnt and Hedgehog (Hh) families have important and conserved roles in metazoan development. These molecules also function postembryonically in homeostatic processes, such as stem cell maintenance. Alterations in these pathways during development cause a variety of congenital disorders and their aberrant activation has been implicated in proliferative disorders leading to many types of human cancer (Logan and Nusse, 2004;Moon et al., 2004). Hh and Wnt signals have been identified as morphogens in various systems. Morphogens are produced from a localized source and spread in the epithelium to form concentration gradients that organize patterning and control growth during development (Tabata and Takei, 2004). The mechanisms of morphogen distribution and the interpretation of morphogen gradients are of fundamental interest.During evolution, organisms have developed many ways to finetune Wnt and Hh signaling. One way of controlling this process is through extracellular modulators that directly interact with Wnt or Hh. It is important to consider how these modulators contribute to the robustness of the gradients and the ability of the cells to measure different morphogen levels. Recently, increasing numbers of cell surface and extracellular modulators have been shown to bind morphogens and to regulate their distribution and signaling. In vertebrates, there are several extracellular modulators of Wnt, including the secreted Frizzled-related protein (SFRP) family (Uren et al., 2000), Cerberus (Willert et al., 2003) and the Wnt inhibitory factor 1 (Wif-1) family (Hsieh et al., 1999).Wif-1 has been described as a secreted antagonist of Wnt signaling (Hsieh et al., 1999;Hunter et al., 2004;Surmann-Schmitt et al., 2009). Hsieh and colleagues have proposed that Wif-1 might sequester Wnt ligands, preventing binding to the receptor Frizzled (Frl) (Hsieh et al., 1999). During development, Wif-1 expression is detectable at early and late stages (Hsieh et al., 1999;Hunter et al., 2004;Surmann-Schmitt et al., 2009). Wif-1 is also expressed in adults in the nervous system, lungs, heart, and cartilage-mesenchyme interfaces of various organisms (Hsieh et al., 1999;Surmann-Schmitt et al., 2009). A relationship between Wif-1 and cancer has also been reported. Thus, human Wif-1 (WIF1) is downregulated in cancers (Mazieres et al., 2004;Kansara et al., 2009) and...

show abstract

“…Before pupariation, Dpp is expressed in a region just anterior to the anteriorposterior compartment boundary, and this produces a gradient of extracellular Dpp that runs through most of the disc (Belenkaya et al, 2004;Teleman and Cohen, 2000). The levels of extracellular BMPs are reduced around wing disc cells that lack either the enzymes required for HS synthesis or the two Drosophila glypicans Dally and Dally-like (Dlp) (Belenkaya et al, 2004;Fujise et al, 2001). Although, in theory, the reduced accumulation of Dpp could be caused by its faster diffusion through the mutant tissue (Lander, 2007), this does not appear to be the case.…”

Section: Bmp Reception and Movement: Context-dependent Effects Of Promentioning

confidence: 99%

The extracellular regulation of bone morphogenetic protein signaling

2009

View full text Add to dashboard Cite

In many cases, the level, positioning and timing of signaling through the bone morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in the extracellular space. Whereas many BMP-binding proteins inhibit signaling by sequestering BMPs from their receptors, other BMP-binding proteins cause remarkably context-specific gains or losses in signaling. Here, we review recent findings and hypotheses on the complex mechanisms that lead to these effects, with data from developing systems, biochemical analyses and mathematical modeling.

show abstract

Regulation of dally, an Integral Membrane Proteoglycan, and Its Function during Adult Sensory Organ Formation of Drosophila

Cited by 70 publications

References 63 publications

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog

The extracellular regulation of bone morphogenetic protein signaling

Contact Info

Product

Resources

About