Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression

Reshef, Ram; Maroto, Miguel; Lassar, Andrew B.

doi:10.1101/gad.12.3.290

Cited by 243 publications

(209 citation statements)

References 54 publications

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“…cause this transcription factor is up-regulated in the paraxial mesoderm by the surface ectoderm (Reshef et al, 1998;Wilm et al, 2004). In that sense, this gene is an excellent marker for the presence of lateral paraxial mesoderm cells in these cultures, which contain surface ectoderm as a source of factors necessary for the survival of the mesoderm.…”

Section: Posterior Im From Stage 8 (Posterior Im8) Is Committed To Itmentioning

confidence: 96%

Cell fate specification along the anterior–posterior axis of the intermediate mesoderm

Barak

Rosenfelder

Schultheiss

et al. 2005

Developmental Dynamics

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The vertebrate intermediate mesoderm (IM) is highly patterned along the anterior-posterior (A-P) axis. In the chick embryo, the kidney tissue, which is a derivative of the IM, is generated only from IM located posterior to the sixth somite axial level, which also marks the border between cranial and trunk segments. The cellular and molecular mechanisms that govern the formation of the anterior border of the kidney morphogenetic field are currently unknown. In this study, we asked whether specific A-P patterning information is conveyed by the movement of cells through the primitive streak (PS) at different time points that consequently affects the expression of kidney genes, or by the environment that these cells encounter during their migration to the IM. In this study, we show that kidney-inductive signals are present along the whole axis, including anterior non-kidney-generating regions. These inductive signals are generated by tissues that are located medial to the anterior IM. We also demonstrate that cells that migrate through the PS of early embryonic stages (Hamburger and Hamilton stage 3-4 and earlier), which will give rise to anterior nonkidney IM, are competent to respond to these inductive factors. This prospective anterior IM tissue loses its competence to respond to kidney inducing signals during its migration from the PS to its final location in the anterior IM. We present here a model in which changes in cell competence determine the formation of the anterior border of kidney gene expression and discuss the possible evolutionary implications of this developmental mechanism. Developmental Dynamics 232:901-914, 2005.

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Section: Posterior Im From Stage 8 (Posterior Im8) Is Committed To Itmentioning

confidence: 96%

Cell fate specification along the anterior–posterior axis of the intermediate mesoderm

Barak

Rosenfelder

Schultheiss

et al. 2005

Developmental Dynamics

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“…In the mouse, noggin-deficient embryos show an increase in Bmp4 expression associated with posterior somite patterning defects, which can be rescued by lowering Bmp4 gene dosage (Wijgerde et al, 2005). In zebrafish embryos, Bmp downregulation by specific inhibitors was also required for upregulation of the myogenic program (Reshef et al, 1998;Row and Kimelman, 2009). Hence, the loss of Bmp signaling in mesoderm progenitor cells seems sufficient to trigger part of the differentiation program associated with somite formation.…”

Section: Aberrant Lineage Differentiationmentioning

confidence: 99%

“…In frog and chick embryos, both gain-and loss-offunction studies identified a role for Bmp4 and Bmpr1 in tailbud outgrowth and somite differentiation (Beck et al, 2001;Reshef et al, 1998;Row and Kimelman, 2009). In zebrafish, loss of Bmp results in ventral fin and tail mesoderm defects (Pyati et al, 2005;Stickney et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud

Sharma¹,

Shafer²,

Bareke³

et al. 2017

Journal of Cell Science

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Caudal somites are generated from a pool of progenitor cells located in the tailbud region. These progenitor cells form the presomitic mesoderm that gradually differentiates into somites under the action of the segmentation clock. The signals responsible for tailbud mesoderm progenitor pool maintenance during axial elongation are still elusive. Here, we show that Bmp signaling is sufficient to activate the entire mesoderm progenitor gene signature in primary cultures of caudal mesoderm cells. Bmp signaling acts through the key regulatory genes brachyury (T ) and Nkx1-2 and contributes to the activation of several other regulators of the mesoderm progenitor gene network. In the absence of Bmp signaling, tailbud mesoderm progenitor cells acquire aberrant gene expression signatures of the heart, blood, muscle and skeletal embryonic lineages. Treatment of embryos with the Bmp inhibitor noggin confirmed the requirement for Bmp signaling for normal T expression and the prevention of abnormal lineage marker activation. Together, these results identify Bmp signaling as a non-cell-autonomous signal necessary for mesoderm progenitor cell homeostasis.

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“…Investigation of the molecular signals controlling somitic development (reviewed by Currie and Ingham, 1998;Saga and Takeda, 2001), suggests that a Sonic hedgehog (Shh) signal emanating from the notochord and floor plate of the neural tube is involved in the induction of sclerotome in the ventromedial somite (Fan and Tessier-Lavigne, 1994;Johnson et al, 1994;Borycki et al, 1998). In contrast, subdivision of the dermomyotome into medial and lateral portions is dependent on competition between bone morphogenetic protein (BMP) signals originating in the dorsal neural tube and lateral plate mesoderm, and Wnt signals (together with BMP inhibitors such as noggin) from the dorsal neural tube (Pourquie et al, 1996;Marcelle et al, 1997;Hissinger et al, 1997;Reshef et al, 1998;Pirskanen et al, 2000). In addition, poorly defined signals from the overlying surface ectoderm, possibly involving Wnt proteins, are also important for somitogenesis (Fan and Tessier-Lavigne, 1994;Fan et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Xenopus bagpipe‐related gene, koza, may play a role in regulation of cell proliferation

Newman

Krieg

2002

Developmental Dynamics

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The homeobox gene koza is a new member of the vertebrate bagpipe-related gene family. Embryonic expression of koza is observed at highest levels in the muscle layer of the somites and, during later development, is restricted to the lateral somitic cells, which correspond to slow twitch muscle tissue. Expression of koza is also observed in the myocardial layer of the heart and in the cement gland. In each of these tissues, koza transcription commences only after the expression of terminal differentiation markers. By injection of synthetic mRNA, we show that overexpression of koza leads to an apparent decrease in the number of cells in the somites. No reduction in cell number is observed when koza is present in neural tissues, suggesting that koza exhibits some tissue specificity in regulation of cell proliferation. Embryonic manipulations show that restriction of koza expression to the slow twitch muscle layer is independent of axial structures but is, at least partly, regulated by signals arising in ectodermal tissue. Finally, in Drosophila, bagpipe expression is regulated by the hedgehog signaling pathway. By using ectopic expression, we show that koza transcription is positively regulated by banded hedgehog. This result indicates that regulation of bagpipe expression by hedgehog signaling is evolutionarily conserved.

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Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression

Cited by 243 publications

References 54 publications

Cell fate specification along the anterior–posterior axis of the intermediate mesoderm

Cell fate specification along the anterior–posterior axis of the intermediate mesoderm

Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud

Xenopus bagpipe‐related gene, koza, may play a role in regulation of cell proliferation

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