Regulation of Drosophila melanogaster pro-apoptotic gene hid

Bilak, Amber; Su, Tin Tin

doi:10.1007/s10495-009-0374-2

Cited by 30 publications

(26 citation statements)

References 47 publications

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“…JNK (also known as the stress-activated protein kinase, SAPK) is a principal cell stress response effector 27,28 that could link all three phenotypes. Activated Drosophila JNK (also referred to as basket) is known to induce apoptosis by activating Hid 29 and autophagy by inducing dFoxo. 30,31 Activated JNK also induces the rupture of crystal cells to release phenoloxidases.…”

Section: Resultsmentioning

confidence: 99%

“…33 While we have yet to assess the abundance and activities of dFoxo and dFos in the Nopp140-depleted larvae, others have shown that Hid induction results from JNK activation via these two transcription factors. 29,39 From the combined evidence, we propose that JNK is a central effector activated in response to perturbations in Drosophila ribosome biogenesis.…”

Section: Uas-c42/uas-c42; P53δ/p53δ (Rnai) (Lane 4) (B) the Cross mentioning

confidence: 99%

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Nucleolar stress in Drosophila melanogaster

James

Cindass²,

Mayer³

et al. 2013

Nucleus

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Section: Resultsmentioning

confidence: 99%

Section: Uas-c42/uas-c42; P53δ/p53δ (Rnai) (Lane 4) (B) the Cross mentioning

confidence: 99%

Nucleolar stress in Drosophila melanogaster

James

Cindass²,

Mayer³

et al. 2013

Nucleus

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“…The accumulation of Hid has been shown to be regulated at both the transcriptional and post-transcriptional level depending on the tissue. 34 In PCs, both Hid protein and hid transcripts accumulate specifically in supernumerary PCs destined to die, indicating upregulation of hid transcription and/or stabilization of hid mRNA. It is important to note, however, that detection of hid expression in PCs was not possible in a wildtype context.…”

Section: Discussionmentioning

confidence: 99%

Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1

et al. 2010

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Although much has been learned in recent years about the apoptotic machinery, the mechanisms underlying survival and death choices during development of metazoans remain less clearly understood. During early oogenesis in Drosophila, a small excess in the number of specialized somatic cells, called polar cells (PCs), produced at follicle extremities is reduced to exactly two cells through apoptosis by mid-oogenesis. We have found that PCs destined to die first lose their apical contacts and then round up and shrink progressively until they disappear. Caspases are activated only once the cells have begun to shrink, suggesting that they are implicated in this part of the process, but not in the initial loss of cell polarity. Loss-of-function analyses based on mutant, clonal and RNAi approaches show that among the RHG family of pro-apoptotic factors, Hid is specifically necessary for PC apoptosis, as well as the initiator caspase Dronc and its adaptor Dark/Apaf-1, and likely several effector caspases, in particular Drice. In addition, we show that Hid protein and transcripts accumulate specifically in PCs destined to die, while the anti-apoptotic factor Diap1 is downregulated in these cells in a hid-dependent manner. Therefore, our results implicate the Hid-Diap1 module as an important regulatory point in a developmental case of apoptosis.

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“…For example, genes like Wrinkled, which plays a role in cell death (Bilak and Su 2009), and sticky, which is involved in cytokinesis (Naim et al 2004), contain SNPs associated with sperm competition in females, but it is not obvious how or whether these genes may affect differential sperm use. Several of the nonneurological genes, such as CG31872 and CG15800, are male-specific genes expressed mainly in the accessory glands or testis, respectively.…”

Section: Association Of Female Snps With Sperm Competitionmentioning

confidence: 99%

Large Neurological Component to Genetic Differences Underlying Biased Sperm Use in Drosophila

2013

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Sperm competition arises as a result of complex interactions among male and female factors. While the roles of some male factors are known, little is known of the molecules or mechanisms that underlie the female contribution to sperm competition. The genetic tools available for Drosophila allow us to identify, in an unbiased manner, candidate female genes that are critical for mediating sperm competition outcomes. We first screened for differences in female sperm storage and use patterns by characterizing the natural variation in sperm competition in a set of 39 lines from the sequenced Drosophila Genetic Reference Panel (DGRP) of wild-derived inbred lines. We found extensive female variation in sperm competition outcomes. To generate a list of candidate female genes for functional studies, we performed a genome-wide association mapping, utilizing the common single-nucleotide polymorphisms (SNPs) segregating in the DGRP lines. Surprisingly, SNPs within ion channel genes and other genes with roles in the nervous system were among the top associated SNPs. Knockdown studies of three candidate genes (para, Rab2, and Rim) in sensory neurons innervating the female reproductive tract indicate that some of these candidate female genes may affect sperm competition by modulating the neural input of these sensory neurons to the female reproductive tract. More extensive functional studies are needed to elucidate the exact role of all these candidate female genes in sperm competition. Nevertheless, the female nervous system appears to have a previously unappreciated role in sperm competition. Our results indicate that the study of female control of sperm competition should not be limited to female reproductive tract-specific genes, but should focus also on diverse biological pathways. I N many organisms, sperm competition is an important source of reproductive variation and is critical to the reproductive success of both males and females. Sperm competition occurs when a female mates with and stores sperm from multiple males. Multiple mating creates a situation in which the males' sperm "compete" for successful fertilizations. While the ultimate outcome of a sperm competition depends on a complex interaction between male and female factors, the sexes often have different interests. Males are essentially in competition with other males, and while natural selection drives males to become better competitors with each other, it may result in males damaging the female through toxicity of seminal proteins (Wigby and Chapman 2004;Mueller et al. 2007). On the other hand, females benefit from simply being able to produce the most and highest-fitness offspring, and this may entail a specific response to male-produced molecules that influence sperm competition. The sexual conflict that arises from these different evolutionary goals of males and females implies that the genetic response to selection on sperm competition may be totally distinct in males and females. It remains largely unknown what genes drive this sexual antagon...

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Regulation of Drosophila melanogaster pro-apoptotic gene hid

Cited by 30 publications

References 47 publications

Nucleolar stress in Drosophila melanogaster

Nucleolar stress in Drosophila melanogaster

Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1

Large Neurological Component to Genetic Differences Underlying Biased Sperm Use in Drosophila

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