Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway

Abstract

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation. Furthermore, BDNF is an effector of estrogen in endometrial cells. Finally, we investigated the different role of Val66Met, a single-nucleotide polymorphism of the BDNF gene, in regulating endometrial cells proliferation. The results showed that BDNF polymorphism is a loss-of-function polymorphism in the regulation of endometrial cells growth. Given the correlation between endometriosis and infertility, it is important to understand the role of BDNF in regulating endometrial cells proliferation and to develop new therapeutic strategies for the treatment of endometriosis-related infertility.

Brain‐derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells

“…BDNF promotes cellular proliferation in various cells (e.g., human endometrial cancer cells; Dong et al, ), but it is unclear as to whether BDNF affects GC proliferation. BDNF promotes the proliferation in the human endometrial cancer cells (Dong et al, ).…”

“…BDNF promotes cellular proliferation in various cells (e.g., human endometrial cancer cells; Dong et al, ), but it is unclear as to whether BDNF affects GC proliferation. BDNF promotes the proliferation in the human endometrial cancer cells (Dong et al, ). The proliferation of goat GCs was diminished by MiR‐10b due to inhibition of BDNF expression (Peng et al, ), and BDNF enhanced proliferation of a human granulosalike tumor cell line (Xie et al, ).…”

“…Interestingly, BDNF is also located in many nonneuronal physiologic systems, such as the reproductive system (Tessarollo, ; Yamamoto, Sobue, Yamamoto, Terao, & Mitsuma, ). BDNF plays an important role in the reproductive system, including functioning in the testis (Li et al, ; Mutter, Middendorff, & Davidoff, ), uterus (Dong et al, ; Mirshokraei, Hassanpour, Rahnama, & Foster, ), and ovary (Martins da Silva et al, ; Sun et al, ; P. Zhao et al, ).…”

Identification of key microRNAs and target genes for the diagnosis of bone nonunion

“…The estrogen signaling pathway plays a key role in regulating the functionality and proliferation of cells in numerous contexts (19)(20)(21)(22). endometrial cell proliferation is regulated via the estrogen-induced brain-derived neurotrophic factor signaling pathway (23,24). it has also been shown that 17βestradiol is able to prevent bone deterioration at least in part via suppressing epha2/ephrina2 signaling (25,26).…”

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

“…In addition, BDNF may be a key factor in chronic pelvic pain of endometriosis, and is an effector of estrogen in endometrial cells, thus affecting cell growth (Dong et al, 2017;Ding et al, 2018). Furthermore, BDNF is the potential target of oleic acid, based on the results of network pharmacology.…”