Regulation of enzyme turnover during tissue differentiation

Betts, S A; Mayer, R. John

doi:10.1016/0304-4165(77)90312-9

Cited by 11 publications

(1 citation statement)

References 18 publications

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“…It should be noted that regulation of glucose 6phosphate dehydrogenase is complex and the process differs among experimental systems. For example, enhancement of glucose 6-phosphate dehydrogenase activity in liver (Rudack et al, 1971;Garcia & Holten, 1975), uterus (Smith & Barker, 1974) and hepatoma (Selmeci & Weber, 1976), and 6-phosphogluconate dehydrogenase activity in liver (Procsal et al, 1976) and mammary gland (Betts & Mayer, 1977), occur via newly synthesized enzyme protein.…”

Section: Resultsmentioning

confidence: 99%

The pentose phosphate pathway in regenerating skeletal muscle

Wagner¹,

Kauffman²,

Max³

1978

Biochemical Journal

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1. The activities of the oxidative enzymes (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and of the non-oxidative enzymes (transaldolase, tranketolase, ribose 5 phosphate isomerase and ribulose 5-phosphate 3-epimerase) of the pentose phosphate pathway were measured at various times during the first 24h of skeletal-muscle regeneration after administration of Marcaine, a mytoxic local anesthetic. 2. The activities of the oxidative enzymes increased after Marcaine injection and rose to 9 times control activities by 24h. 3. The activities of all non-oxidative enzymes were increased after Marcaine administration, but to a much smaller extent than the oxidative enzymes (1.1-1.7-fold). 4. Histochemical analysis localized glucose 6-phosphate dehydrogenase activity within muscle fibres of control and Marcaine-treated muscles. 5. Cycloheximide or actinomycin D prevented the increase in oxidative enzyme activities, suggesting a requirement for synthesis of protein and RNA.

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Section: Resultsmentioning

confidence: 99%

The pentose phosphate pathway in regenerating skeletal muscle

Wagner¹,

Kauffman²,

Max³

1978

Biochemical Journal

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Neuroleptic-induced Prolactin Level Elevation and Breast Cancer

Schyve

Smithline

Meltzer

1978

Arch Gen Psychiatry

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Polymer Hydrogels to Guide Organotypic and Organoid Cultures

Magno

Meinhardt

Werner

2020

Adv Funct Materials

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Human organotypic and organoid cultures provide increasingly lifelike models of tissue/organ development and disease, enable more realistic drug screening, and may ultimately pave the way for new therapies. A broad variety of extracellular matrix-based or inspired materials is instrumental in these approaches. In this review article, the foundations of the related materials design are summarized with an emphasis on the advantages and limitations of decellularized and reconstituted biopolymeric matrices as well as biohybrid and fully synthetic polymer hydrogel systems applied to enable specific organotypic and organoid cultures. Recent progress in the fabrication of defined hydrogel systems offering thoroughly tunable biochemical and biophysical properties is highlighted. Potentialities of hydrogel-based approaches to address the persisting challenges of organoid technologies, namely scalability, connectivity/integration, reproducibility, parallelization, and in situ monitoring are discussed.

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Regulation of enzyme turnover during tissue differentiation

Cited by 11 publications

References 18 publications

The pentose phosphate pathway in regenerating skeletal muscle

The pentose phosphate pathway in regenerating skeletal muscle

Neuroleptic-induced Prolactin Level Elevation and Breast Cancer

Polymer Hydrogels to Guide Organotypic and Organoid Cultures

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