Regulation of Eukaryotic Translation

Initiation of protein synthesis in mammalian cells

“…Several reviews cover work published up to about 1982 [7][8][9][10]. In addition, two full-length reviews appeared more recently, one dealing with certain specific aspects of regulation [11] and the other a well-balanced account of current views of mechanism [12]. Here I aim to summarize present knowledge of the mechanism of initiation of protein synthesis in mammalian cells, and of its quantitative regulation, with particular reference to the most recent developments.…”

The 5′-Untranslated Region of Picornaviral Genomes

“…The phosphorylated form of eIF-2 is, in turn, a potent inhibitor of the eIF-2B activity. The complex and physiologically important controls involving the eIF-2 system have recently been the subject of several reviews (Kaempfer, 1984;London et al, 1987;Gupta et al, 1987;Hershey, 1989;Sarre, 1989).…”

“…The problem has several facets. One was set forth by R. Kaempfer and associ-ates, who proposed that eIF-2, in addition to its canonical function in guiding Met-tRNA, to ribosomes, promotes ribosome binding to certain templates, particularly to cardiovirus (mengovirus) RNA, and probably takes part in the selection of proper AUGs as well (reviewed by Kaempfer, 1984). These proposals were based on several considerations.…”