2000
DOI: 10.1172/jci9290
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Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells

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Cited by 107 publications
(83 citation statements)
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“…At 39°C the transfectants (LVCaP cells) express mutant p53, whereas at 32°C these cells express a functionally wild-type p53 protein. 19 As shown in Figure 2A, LVCaP cells cultured at 32°C expressed lower levels of EMMPRIN as compared to the cells cultured at 39°C. To verify the effect of p53 on EMMPRIN expression, we transfected the p53-null cells, PC-3, with a wildtype p53 expression vector and then measured the expression of EMMPRIN protein.…”
Section: Effects Of P53 Status On Emmprin Protein Expressionmentioning
confidence: 80%
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“…At 39°C the transfectants (LVCaP cells) express mutant p53, whereas at 32°C these cells express a functionally wild-type p53 protein. 19 As shown in Figure 2A, LVCaP cells cultured at 32°C expressed lower levels of EMMPRIN as compared to the cells cultured at 39°C. To verify the effect of p53 on EMMPRIN expression, we transfected the p53-null cells, PC-3, with a wildtype p53 expression vector and then measured the expression of EMMPRIN protein.…”
Section: Effects Of P53 Status On Emmprin Protein Expressionmentioning
confidence: 80%
“…Temperature-sensitive p53 transfectant, LVCaP line, was established and cultured as previously described. 19 Human glioblastoma T98G cells were maintained in F-10 media; human breast cancer MCF-7 cells and ovarian carcinoma NCI/ADR-RES cells were cultured in RPMI-1640 media. All of the media contain 10% fetal bovine serum, 100 units/ml penicillin and 100 μg/ml streptomycin.…”
Section: Methodsmentioning
confidence: 99%
“…50 Interestingly, it has been reported that wild-type p53 represses MDR1 or MRP1 in colon cancer. [51][52][53] This was recently corroborated in cell cultures by the fact that a loss of p53 repression leads specifically to MDR1 but not MRP1 up-regulation, 54 following a mechanism that involves an exclusive interaction between a p53 mutant (not wt-p53) and an Ets binding site in the MDR1 promoter.…”
Section: Discussionmentioning
confidence: 94%
“…Sullivan et al 53 have reported a mechanistic linkage between the expression of MRP1 and mutant p53. MRP1 was induced by transfecting cancer cells with p53 inactivated by papilloma virus or with a dominant negative mutant of p53.…”
Section: Discussionmentioning
confidence: 99%