2007
DOI: 10.1016/j.tins.2007.03.003
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Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

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Cited by 931 publications
(923 citation statements)
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References 61 publications
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“…Dopamine roles in reward learning, prediction, and motivation A popular alternative interpretation of mesolimbic dopamine's role in reward has been that it mediates learning and predictions about future reward events. This alternative draws on the distinction between phasic dopamine signals (spike-triggered release limited to within synapses) and tonic dopamine signals (spike-independent release extending outside synapses) and typically assigns a learning role specifically to phasic signals (Grace 1991;Grace et al 2007;Niv et al 2007;Phillips et al 2003;Schultz 1997;. Learning and prediction roles of dopamine have been conceptualized as teaching signals, S-S prediction signals about future rewards, and S-R stamping-in or habit reinforcement ( Schultz et al 1997;Tobler et al 2005) and by target systems in nucleus accumbens and related forebrain structures (Aldridge et al 1993;Barnes et al 2005;Carelli 2004;Cromwell et al 2005;Day and Carelli 2007;Ghitza et al 2004;Roitman et al 2005;Taha and Fields 2006;Tindell et al 2004;Wan and Peoples 2006).…”
Section: Controversial Subcortical Pleasure Generators? Dopamine and mentioning
confidence: 99%
“…Dopamine roles in reward learning, prediction, and motivation A popular alternative interpretation of mesolimbic dopamine's role in reward has been that it mediates learning and predictions about future reward events. This alternative draws on the distinction between phasic dopamine signals (spike-triggered release limited to within synapses) and tonic dopamine signals (spike-independent release extending outside synapses) and typically assigns a learning role specifically to phasic signals (Grace 1991;Grace et al 2007;Niv et al 2007;Phillips et al 2003;Schultz 1997;. Learning and prediction roles of dopamine have been conceptualized as teaching signals, S-S prediction signals about future rewards, and S-R stamping-in or habit reinforcement ( Schultz et al 1997;Tobler et al 2005) and by target systems in nucleus accumbens and related forebrain structures (Aldridge et al 1993;Barnes et al 2005;Carelli 2004;Cromwell et al 2005;Day and Carelli 2007;Ghitza et al 2004;Roitman et al 2005;Taha and Fields 2006;Tindell et al 2004;Wan and Peoples 2006).…”
Section: Controversial Subcortical Pleasure Generators? Dopamine and mentioning
confidence: 99%
“…To fully understand the effects of the COMT genotype on cognition, it may be necessary to consider whether a task requires tonic or phasic dopaminergic activation (Bilder, et al, 2004;Grace, et al, 2007). The tonic component is characterized by a constant, slow, irregular firing of DA neurons, whereas the phasic component is characterized by transient, high-amplitude activity, so-called burst firing.…”
Section: How To Explain the Positive Effect Of Met Genotype Loading Omentioning
confidence: 99%
“…These data provide evidence in favour of a recent model suggesting a functional hippocampal-SN/VTA loop of novelty-processing and encoding (Lisman & Grace, 2005). Furthermore, dopamine plays a critical role in regulating the subcortical flow of information between medial temporal structures such as the hippocampus and prefrontal cortex (Grace, Floresco, Goto, & Lodge, 2007). Hence, dopaminergic dysfunction in aging should impact on novelty processing, long-term consolidation as well as on learning tasks that depend on the functional interplay between prefrontal and medial temporal brain regions.…”
Section: Introductionmentioning
confidence: 41%
“…Dopamine also modulates prefrontal and medial temporal processing, as well as the interaction between medial temporal and prefrontal processing (Grace et al, 2007). To the extent that reductions in SN/VTA MTR are associated with diminished dopaminergic neurotransmission, this may be associated with triple impact upon CVLT: First, there may be a reduction of MTL responses to novelty.…”
Section: Discussionmentioning
confidence: 99%