Regulation of fluid and electrolyte balance

Louden, Jonathan D.

doi:10.1016/j.mpaic.2012.04.009

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…In mammals, the regulation of plasmatic osmolality is an essential physiological mechanism for normal development (Hussy et al 2000 ). Regulation of the osmolality of extracellular fluids is achieved by balancing the intake and excretion of salts and water (Louden 2012 ). The neuroendocrine hypothalamo-neurohypophysial system responsible for this physiological regulation consists of neurons located in the paraventricular (PVN) and supraoptic nuclei (SON).…”

Section: Introductionmentioning

confidence: 99%

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

Boumansour

Benhafri

Guillon

et al. 2021

Animal Cells and Systems

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In mammals, plasmatic osmolality needs to be stable, and it is highly related to the hydric state of the animals which depends on the activity of the hypothalamic neurohypophysial system and more particularly by vasopressin secretion. Meriones, a desert rodent, can survive even without drinking for more than one month. The mechanism(s) by which they survive under these conditions remains poorly understood. In this study, we examine the water's deprivation consequences on the: (1) anatomy, morphology, and physiology of the hypothalamic supraoptic nucleus, (2) body mass and plasma electrolytes changes in male desert rodents 'Meriones libycus' subjected to water deprivation for 30 days. The effect of water deprivation was evaluated on the structural and cellular organization of the supraoptic nucleus by morphological observations and immunohistochemical approaches, allowing the labeling of AVP but also oxytocin. Our finding demonstrated that upon water deprivation (1) the body weight decreased and reached a plateau after a month of water restriction. (2) The plasmatic osmolality began to decrease and return to values similar to control animals at day 30. (3) The SON, both in hydrated and water-deprived animals, is highly developed.(4) The AVP labeling in the SON increased upon dehydration at variance with OT. These changes observed in body mass and plasma osmolality reveal an important adaptive process of male Meriones in response to prolonged water deprivation. Overall, this animal represents an interesting model for the study of water body homeostasis and the mechanisms underlying the survival of desert rodents to xeric environments.

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Section: Introductionmentioning

confidence: 99%

Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus

Boumansour

Benhafri

Guillon

et al. 2021

Animal Cells and Systems

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“…It not only provides a buffered environment for most biochemical reactions, but also circulates inside the body to bring various substances to the right place for normal physiological activities ( Bianchetti et al., 2009 ). Therefore, maintaining the dynamic balance of fluid composition, capacity, and distribution is critical for the life ( Louden, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

“…The antidiuretic hormone (ADH) is a nine-amino-acid peptide synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. It migrates along the axons of supraoptic and paraventricular neurons to enter the posterior pituitary to be released in to the blood ( Louden, 2012 ). Human ADH, which is also known as arginine vasopressin (AVP), could bind to the arginine vasopressin receptor 2 (AVPR2) in the medullary and cortical collecting ducts in the kidney ( Juul et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…Human ADH, which is also known as arginine vasopressin (AVP), could bind to the arginine vasopressin receptor 2 (AVPR2) in the medullary and cortical collecting ducts in the kidney ( Juul et al., 2014 ). This alters the activity of aquaporin 2 (AQP2) and increases the permeability of the collecting ducts to water, results in more efficient reabsorption and more concentrated urine ( Louden, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Codonopsis Radix modulates water and electrolytes homeostasis in mice

Chen

2021

Heliyon

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Codonopsis Radix is a traditional Chinese medicine best known for its effects in treating digestive, cardiovascular, immunological and hematopoitic diseases. It also appears in the traditional Chinese medical prescriptions against ascites. However, the physiological effect and molecular mechanism of Codonopsis Radix in water and electrolytes homeostasis have not been well studied. We found that Codonopsis Radix decoction increased water intake and the urine volume, but decreased food intake in mice. The treatment significantly reduced angiotensin II receptor (AT1R) transcription and serum aldosterone level in animals, suggested perturbed function of renin-angiotensin system. RNAseq analysis of Codonopsis Radix treated NCI–H295R cells detected suppressed AT1R, SP1, and TEF transcription as well. Thus, Codonopsis Radix may regulate water and electrolytes homeostasis by affecting AT1R expression and aldosterone biosynthesis, possibly through downregulating SP1 and TEF transcription.

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“…The constancy of the concentration of electrolyte elements in plasma, such as sodium and potassium, are of paramount importance for the functioning of metabolism (1). The occurrence of plasma changes of these electrolytes causes systemic damage to the body.…”

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confidence: 99%