2008
DOI: 10.1038/sj.onc.1211027
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Regulation of glioblastoma cell invasion by PKCι and RhoB

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Cited by 58 publications
(56 citation statements)
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References 35 publications
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“…It participates in diverse cellular process including actin organization, differentiation to block cell migration activity. Introduction of exogenous RhoB suppresses glioma cell mobility and invasiveness by reducing activation of PKC iota and PKB/AKT 48. MiR‐19 is reported to promote glioma cell invasion and migration by directly suppressing RhoB by miR‐19 25.…”
Section: Mir‐19 In Gliomamentioning
confidence: 99%
“…It participates in diverse cellular process including actin organization, differentiation to block cell migration activity. Introduction of exogenous RhoB suppresses glioma cell mobility and invasiveness by reducing activation of PKC iota and PKB/AKT 48. MiR‐19 is reported to promote glioma cell invasion and migration by directly suppressing RhoB by miR‐19 25.…”
Section: Mir‐19 In Gliomamentioning
confidence: 99%
“…In these cells, PKCi is activated by loss of PTEN rather than by PIK3CA mutation (Baldwin et al, 2008).…”
Section: Pkci Represses Senescence In Glioblastomamentioning
confidence: 99%
“…It is overexpressed in multiple cancer types, and studies of both mouse models and human cancer cell lines show an important role in the growth, invasion and resistance to apoptosis of a variety of cancer cell types. In glioblastoma, PKCi represses apoptosis and promotes invasion (Baldwin et al, 2006(Baldwin et al, , 2008. PKCi also has a key role in the pathogenesis of lung, ovarian and pancreatic cancer (Eder et al, 2005;Regala et al, 2005;Zhang et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…A synergistic effect of TAM with radiation in C6 glioma cells has been demonstrated, and may partially be due to the inhibition of PKC activation (18). The atypical PKC family member, PKC-ι was of particular interest as it is a key regulator of cell survival, proliferation, invasion and chemoresistance in glioma (27,30,34,35). The present results revealed an inhibitory role of TAM in the expression levels of p-PKC-ι, which may participate in the radioresistance of glioma cells.…”
Section: Discussionmentioning
confidence: 99%