Regulation of Glyceraldehyde 3-Phosphate Dehydrogenase Expression by Metformin in HepG2 Cells

Abstract

Biguanides are known to have a serious side effect, lactic acidosis. We previously reported that buformin suppressed the expression of glyceraldehyde 3-phosphate dehydrogenase (GAPD) and suggested that this decrease was one of the causes of lactic acidosis. In this study, we examined the signaling pathway and regulatory Key words metformin; glyceraldehyde 3-phosphate dehydrogenase; adenylate cyclase; protein kinase A; AMP-activated protein kinase; cAMP-response element binding protein