Regulation of Hippocampal Synaptic Plasticity by the Tyrosine Kinase Receptor, REK7/EphA5, and its Ligand, AL-1/Ephrin-A5

Wq, Gao; Shinsky, Natasha; Mp, Armanini; Moran, Paul; Jl, Zheng; Jl, Mendoza-Ramirez; Hs, Phillips; Jw, Winslow; Caras, Ingrid W.

doi:10.1006/mcne.1998.0696

Cited by 69 publications

(40 citation statements)

References 37 publications

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“…It will be interesting to determine whether EphA4-dependent Rap inactivation is responsible for the long-term potentiation-like effects observed after stimulation of hippocampal slices with an ephrin-A Fc ligand (Gao et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

Richter

Murai²,

Bourgin³

et al. 2007

J. Neurosci.

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Section: Discussionmentioning

confidence: 99%

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

Richter

Murai²,

Bourgin³

et al. 2007

J. Neurosci.

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“…Specifically, animals exhibited elevated fear responses consequent to shock exposure following EphA5 receptor agonist infusion. These behavioral changes were also accompanied by alterations in long-term potentiation suggesting the role of EphA5 receptor in synaptic plasticity (Gao et al, 1998b). In addition, Halladay et al (2004) showed that animals expressing a truncated EphA5 receptor exhibited learning deficits in striatal-dependent tasks.…”

Section: Introductionmentioning

confidence: 95%

Changes in attack behavior and activity in EphA5 knockout mice

et al. 2008

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During development, Eph tyrosine kinase receptors and their ephrin ligands function as axon guidance molecules while, in adults, these molecules appear to be involved in the regulation of neural plasticity and emotion. The absence of EphA5 receptor mediated forward signaling may cause alterations in connectivity of neural networks and boundary formation during development, including central monoaminergic systems. In the present studies, we demonstrated altered aggressive responses by animals lacking functional EphA5 receptors. These behavioral changes were accompanied by altered concentrations of serotonin (5-HT) and the metabolite, 5-HIAA, in the hypothalamus. The changes of serotonin activity in hypothalamus also result in increase of body weight in EphA5 knockout mice. Furthermore, EphA5 knockout mice exhibited a significant decrease in activity levels following exposure to naïve intruders in their home cages. We conclude that the EphA5 receptor may be involved in mediation of aggressive behavior regulated, in part, by hypothalamic serotonin.

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“…Similarly, application of soluble EphA5-IgG in hippocampal slices impairs the induction of LTP [27]. Conversely, activation of endogenous EphAs by clustered ephrinA5-IgG increased synaptic transmission and improved learning [27,29]. These results indicate that the EphA/ephrinA interaction may be required for all phases of LTP at the CA3-CA1 synapse.…”

Section: Eph Receptor Forward Signaling In Synapse Formation and Plasmentioning

confidence: 90%

“…Perturbing endogenous EphA/ephrinA interaction by infusing recombinant immunoadhesins that specifically bind to the receptor binding site of the ephrin-A ligand in vivo impaired hippocampal-dependent learning [30]. Similarly, application of soluble EphA5-IgG in hippocampal slices impairs the induction of LTP [27]. Conversely, activation of endogenous EphAs by clustered ephrinA5-IgG increased synaptic transmission and improved learning [27,29].…”

Section: Eph Receptor Forward Signaling In Synapse Formation and Plasmentioning

confidence: 99%

Bidirectional ephrin/Eph signaling in synaptic functions

Aoto¹,

Chen²

2007

Brain Research

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Eph receptors, the largest family of receptor tyrosine kinases, and their membrane bound ligands, the ephrins, are involved in multiple developmental and adult processes within and outside of the nervous system. Bi-directional signaling from both the receptor and the ligand is initiated by ephrinEph binding upon cell-cell contact, and involves interactions with distinct subsets of downstream signaling molecules related to specific functions. In the CNS, Ephs and ephrins act as attractive/ repulsive, migratory, and cell adhesive cues during development and participate in synaptic functions in adult animals. In this review, we will focus on recent findings highlighting the functions of ephrin/ Eph signaling in dendritic spine morphogenesis, synapse formation, and synaptic plasticity.

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Regulation of Hippocampal Synaptic Plasticity by the Tyrosine Kinase Receptor, REK7/EphA5, and its Ligand, AL-1/Ephrin-A5

Cited by 69 publications

References 37 publications

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

The EphA4 Receptor Regulates Neuronal Morphology through SPAR-Mediated Inactivation of Rap GTPases

Changes in attack behavior and activity in EphA5 knockout mice

Bidirectional ephrin/Eph signaling in synaptic functions

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