Regulation of Inflammatory Reaction in Health and Disease

Fioranelli, Massimo; Flavin, Dana; Linda, Cota

doi:10.3390/ijms22105277

Cited by 63 publications

(35 citation statements)

References 52 publications

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“…Some proteins, such as β-catenin and COX-2, are closely associated with wound healing ( Li et al, 2016 ; Chen et al, 2017 ). Inflammation is an integrative process driven by a number of mediators which regulate specific aspects of the inflammatory response ( Fioranelli et al, 2021 ). Under normal conditions, inflammatory reactions will promote the proliferation of adult fibroblasts ( Carre et al, 2010 ), up-regulate the production of β-catenin ( Schunk et al, 2021 ), COX-2, and the secretion of prostaglandins ( Enzerink et al, 2010 ), activate vascular endothelial growth factors (VEGFs), and promote wound healing by facilitating wound angiogenesis and accelerating blood supply ( de Oliveira et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil

Yin¹,

Hong²,

Tang³

et al. 2022

Front. Pharmacol.

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ShengFu oil is a compounded Chinese medicinal prescription, and provides antibacterial, anti-inflammatory, and analgesic effects, favoring burn wound repair. In this study, we aimed at investigating the effects of topical applications of ShengFu oil and its active ingredients in oral chemical burns and elucidating its regulatory effects on β-catenin, COX-2, and MMP-9 expression caused by exposure to acid or alkaline agents. ShengFu oil contains 16 components, such as Frankincense, Radix Scutellariae and Radix Rehmanniae, and the main active ingredients from Frankincense are α-pinene, linalool, and n-octanol. Mouse models of oral chemical burns were induced by using glacial acetic acid or sodium hydroxide. Hematoxylin and eosin staining and immunohistochemical staining were used to detect the protein expressions of β-catenin, COX-2, and MMP-9 in wound tissues. They were further quantified by multispectral imaging analysis to clarify the effective mechanism of ShengFu oil for intervening inflammatory factors and active components. Our results indicated that the application of ShengFu oil on oral chemical burns effectively stopped the oral burn bleeding and reduced the inflammatory reaction in the damaged tissues, demonstrating that ShengFu oil can promote wound tissue repair in burns caused by heat, acids, and alkalis. The immunohistochemical staining results illustrated that ShengFu oil and its active ingredients significantly reversed the abnormal changes in inflammation-related proteins in mouse tongue tissues that were caused by chemical burns. Regarding long-term toxic effects of ShengFu oil on the gastrointestinal tract, liver, and kidney system, the results of hematoxylin and eosin staining experiments depicted that ShengFu oil was safe and effective for liver, kidney, intestine, esophagus, and tongue. All of these demonstrated that ShengFu oil and its active ingredients are effective and safe in preventing and treating oral chemical burns by interfering with the inflammatory microenvironment.

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Section: Discussionmentioning

confidence: 99%

Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil

Yin¹,

Hong²,

Tang³

et al. 2022

Front. Pharmacol.

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show abstract

“…The initiation of a specific immune response depends on the recognition of the foreign nature of an antigen as well as the conditions under which the given antigen is presented to immunocompetent cells: if the conditions are interpreted by the organism as pathological, they will trigger an immune response regardless of whether the antigen is the organism's own or foreign [87]. In the case of auto-aggression, the signal inducing the immune response may originate from an inflammation accompanying the release of antigens due to damage [88]. The immunological markers of type 1 diabetes include antibodies active against pancreatic β cells: Islet-cell antibodies (ICA), insulin autoantibodies (IAA), anti-glutamine acid decarboxylase (anti-GAD), anti-zinc transporter protein 8 (anti-ZnT8), and anti-tyrosine phosphatase antibodies (anti-IA2) [89].…”

Section: Autoimmune Disordersmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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The physiological markers of autoimmune diabetes include functional disorders of the antioxidative system as well as progressing inflammation and the presence of autoantibodies. Even though people with type 1 diabetes show genetic predispositions facilitating the onset of the disease, it is believed that dietary factors can stimulate the initiation and progression of the disease. This paper analyses the possibility of using tea as an element of diet therapy in the treatment of type 1 diabetes. Based on information available in literature covering the last 10 years, the impact of regular tea consumption or diet supplements containing tea polyphenols on the oxidative status as well as inflammatory and autoimmune response of the organism was analyzed. Studies conducted on laboratory animals, human patients, and in vitro revealed positive effects of the consumption of tea or polyphenols isolated therefrom on the diabetic body. Few reports available in the literature pertain to the impact of tea on organisms affected by type 1 diabetes as most (over 85%) have focused on cases of type 2 diabetes. It has been concluded that by introducing tea into the diet, it is possible to alleviate some of the consequences of oxidative stress and inflammation, thus limiting their destructive impact on the patients’ organisms, consequently improving their quality of life, regardless of the type of diabetes. Furthermore, elimination of inflammation should reduce the incidence of immune response. One should consider more widespread promotion of tea consumption by individuals genetically predisposed to diabetes, especially considering the drink’s low price, easy availability, overall benefits to human health, and above all, the fact that it can be safely used over extended periods of time, regardless of the patient’s age.

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“…In some situations, humans lose the capacity to control this reaction and its long-term existence results in a chronic systemic inflammatory state [ 87 ]. Uncontrolled and prolonged inflammatory processes are implicated in the etiology of many chronic conditions, such as cancer, asthma, diabetes mellitus, chronic kidney, cardiovascular, osteo-degenerative, and non-alcoholic fatty liver diseases as well as autoimmune and neurodegenerative disorders [ 88 , 89 , 90 ]. To abrogate the burden of inflammatory diseases in man, a number of interventions are already in place, such as the use of anti-inflammatory drugs and natural compounds [ 91 , 92 ].…”

Section: Biological Activities Of Ldpsmentioning

confidence: 99%

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

et al. 2021

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There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of Lupinus species (Lupin), a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties. This paper discusses the intestinal transport, bioavailability and biological activities of LDPs, focusing on molecular mechanisms of action as reported in in vitro, cell culture, animal and human studies. The potentials of several LDPs to demonstrate multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, and antioxidant and anti-inflammatory activities position LDPs as good candidates for nutraceutical development for the prevention and management of medical conditions whose etiology are multifactorial.

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Regulation of Inflammatory Reaction in Health and Disease

Cited by 63 publications

References 52 publications

Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil

Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

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