Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways

Zhang, Yi; Li, Xuefeng; Han, Lifeng; Gao, Xiumei; Liu, Erwei; Wang, Tao

doi:10.1016/j.foodchem.2013.05.121

Cited by 55 publications

(43 citation statements)

References 35 publications

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“…Dietary 0.28% MS supplementation decreased the GLU content in plasma at the age of 42 d, which is in accordance with a previous study [21]. Furthermore, no differences in ALT and AST activities and TP and ALB contents were observed with dietary MS supplementation in the present study.…”

Section: Discussionsupporting

confidence: 93%

“…The meat quality was reported to be affected by the lipid metabolism in broilers [19], and the muscle energy metabolism was also an important factor for determining the final meat quality of animals through glycogen metabolism or TG accumulation [20]. A previous study showed that the mango leave extract played a dominant role in the integrated regulation of sugar and lipid homeostasis in vitro and in vivo , and the ethanolic extract of mango leaves decreased plasma GLU and TG contents in a dose-dependent manner in mice [21]. Similarly, lower plasma TC, TG, and GLU contents were observed in the 0.28% MS treatment.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices

Zhang

Wang

et al. 2016

Asian-Australas J Anim Sci

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ObjectiveThe objective of the present study was to determine whether mango saponin (MS) could be used as a feed additive in broiler chicks by evaluating growth performance, carcass characteristics, meat quality, and plasma biochemical indices.MethodsA total of 216 1-d-old Arbor Acres male broiler chicks were randomly assigned into three dietary treatments supplemented with 0 (control), 0.14% (MS 0.14%), or 0.28% (MS 0.28%) MS. Each treatment had six replicates (cages) with 12 chicks each. The feeding trial lasted for six weeks.ResultsCompared with the control, dietary supplemented with 0.14% or 0.28% MS increased average daily weight gain of chicks in the grower (22 to 42 d) and the whole (1 to 42 d) phases, and the final body weight of chicks on d 42 was higher in MS supplemented groups (p<0.05). Lower L45 min* (lightness) and L24 h* values, lower b24 h* (yellowness) value, and higher a45 min* (redness) and a24 h* values of the breast muscle were observed in chicks fed with 0.28% MS on d 42 (p<0.05). The total antioxidant capacity in plasma increased in MS 0.14% group on d 21 (p<0.001). Lower contents of plasma total cholesterol and triglyceride were observed in chicks fed with 0.28% MS on d 21 and d 42, whereas the group supplemented with 0.14% MS only decreased plasma triglyceride content on d 21 (p<0.05). The glucose content in plasma decreased in MS 0.28% group on d 42 (p<0.001).ConclusionOverall, MS could be used as a feed additive in broiler chicks, and the supplemental level of 0.28% MS in diet could improve growth performance, meat quality, and plasma lipid metabolism in broiler chicks.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices

Zhang

Wang

et al. 2016

Asian-Australas J Anim Sci

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“…A flavonoid isolated from rutin enhances insulin-dependent receptor kinase activity and GLUT4 translocation in differentiated muscle myotubes and thereby improves glucose uptake (18). Mango leaf extract affects glucose and lipid homeostasis in vitro and in vivo through the PI3K/ Akt and Adenosine monophosphate-activated protein kinase (AMPK) signaling pathways (19). Bamboo leaf extract treatment could increase the phosphorylated Akt level in renal tissues of rats with diabetes (20).…”

mentioning

confidence: 99%

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Shih

Chen

Varga

et al. 2020

Food & Nutrition Research

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“…Maclurin-3-C-glucoside (2), vicenin-2 (6), eriocitrin (7), phloretin-169 3′,5′-di-C-glucoside (8) and hesperidin (9) in the sample extracts were identified by co-elution with …”

mentioning

confidence: 99%

Thermal Degradation Kinetics Modeling of Benzophenones and Xanthones during High-Temperature Oxidation of Cyclopia genistoides (L.) Vent. Plant Material

Beelders

Beer

Joubert

2015

J. Agric. Food Chem.

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Degradation of the major benzophenones, iriflophenone-3-C-glucoside-4-O-glucoside and iriflophenone-3-C-glucoside, and the major xanthones, mangiferin and isomangiferin, of Cyclopia genistoides followed first-order reaction kinetics during high-temperature oxidation of the plant material at 80 and 90 °C. Iriflophenone-3-C-glucoside-4-O-glucoside was shown to be the most thermally stable compound. Isomangiferin was the second most stable compound at 80 °C, while its degradation rate constant was influenced the most by increased temperature. Mangiferin and iriflophenone-3-C-glucoside had comparable degradation rate constants at 80 °C. The thermal degradation kinetic model was subsequently evaluated by subjecting different batches of plant material to oxidative conditions (90 °C/16 h). The model accurately predicted the individual contents of three of the compounds in aqueous extracts prepared from oxidized plant material. The impact of benzophenone and xanthone degradation was reflected in the decreased total antioxidant capacity of the aqueous extracts, as determined using the oxygen radical absorbance capacity and DPPH(•) scavenging assays.

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Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways

Cited by 55 publications

References 35 publications

Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices

Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Thermal Degradation Kinetics Modeling of Benzophenones and Xanthones during High-Temperature Oxidation of Cyclopia genistoides (L.) Vent. Plant Material

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