Regulation of Male and Female Reproductive Functions

Al-Suhaimi, Ebtesam A.; Khan, Firdos Alam; Homeida, A. M.

doi:10.1007/978-981-16-9016-7_9

Cited by 8 publications

(3 citation statements)

References 101 publications

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“…POI is particularly detrimental in children with a cancer diagnosis prior to puberty, where hormonal loss can impact the maintenance of homeostasis between the ovaries and other tissues and endocrine organs [8][9][10][11][12]. Changes during puberty also promote physical and psychological development into adulthood and can determine height, bone health, insulin responsiveness, lipid metabolism, cardiovascular health, and cognition [5,13]. These changes are orchestrated by the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which regulates the release of gonadotropins, luteinizing (LH), and follicle-stimulating (FSH) hormones from the pituitary.…”

Section: Introductionmentioning

confidence: 99%

Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice

et al. 2023

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Transplantation of allogeneic donor ovarian tissue holds great potential for female cancer survivors who often experience premature ovarian insufficiency. To avoid complications associated with immune suppression and to protect transplanted ovarian allografts from immune-mediated injury, we have developed an immunoisolating hydrogel-based capsule that supports the function of ovarian allografts without triggering an immune response. Encapsulated ovarian allografts implanted in naïve ovariectomized BALB/c mice responded to the circulating gonadotropins and maintained function for 4 months, as evident by regular estrous cycles and the presence of antral follicles in the retrieved grafts. In contrast to non-encapsulated controls, repeated implantations of encapsulated mouse ovarian allografts did not sensitize naïve BALB/c mice, which was confirmed with undetectable levels of alloantibodies. Further, encapsulated allografts implanted in hosts previously sensitized by the implantation of non-encapsulated allografts restored estrous cycles similarly to our results in naïve recipients. Next, we tested the translational potential and efficiency of the immune-isolating capsule in a rhesus monkey model by implanting encapsulated ovarian auto- and allografts in young ovariectomized animals. The encapsulated ovarian grafts survived and restored basal levels of urinary estrone conjugate and pregnanediol 3-glucuronide during the 4- and 5-month observation periods. We demonstrate, for the first time, that encapsulated ovarian allografts functioned for months in young rhesus monkeys and sensitized mice, while the immunoisolating capsule prevented sensitization and protected the allograft from rejection.

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Section: Introductionmentioning

confidence: 99%

Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice

et al. 2023

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“…Progestogen defines the category of hormone molecules that act like progesterone in theuterus [6]. Progesterone plays a crucial role in regulating cell proliferation and differentiation in female reproductive processes [7]. The term "progestin" is commonly used to encompass both natural progesterone and a range of synthetic hormone molecules.…”

Section: Introductionmentioning

confidence: 99%

Targeting Human progesterone receptor (PR), through Pharmacophore- based screening and molecular simulation revealed potent inhibitors against breast cancer

Shahab,

Ziyu,

Zheng

et al. 2023

Preprint

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Breast cancer, the prevailing malignant tumor among women, is linked to progesterone and its receptor (PR) in both tumorigenesis and treatment responsiveness. Despite thorough investigation, the precise molecular mechanisms of progesterone in breast cancer remain unclear. The human progesterone receptor (PR) serves as an essential therapeutic target for breast cancer treatment, warranting the rapid design of small molecule therapeutics that can effectively inhibit HPR. By employing cutting-edge computational techniques like molecular screening, simulation, and free energy calculation, the process of identifying potential lead molecules from natural products has been significantly expedited. In this study, we employed pharmacophore-based virtual screening and molecular simulations to identify natural product-based inhibitors of human progesterone receptor (PR) in breast cancer treatment. High-throughput molecular screening of Traditional Chinese Medicine (TCM) and zinc databases was performed, leading to the identification of potential lead compounds. The analysis of binding modes for the top two compounds from each database provides valuable structural insights into the inhibition of HPR for breast cancer treatment. The top four hits exhibited enhanced stability and compactness compared to the reference compound. In conclusion, our study provides valuable insights for identifying and refining lead compounds as HPR inhibitors.

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“…There are several follicles in the body; the most well-known ones are those found in the ovary, hair, and thyroid. Comprising the female gamete, or oocyte, and supporting somatic cells, the ovarian follicle is the anatomical and functional unit of the ovary (1).…”

Section: Introductionmentioning

confidence: 99%

Structural variations and distributions of human Body follicles

2022

jjoas-n

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Background: Mammals have a special characteristic called a follicles, where other structures or materials can form and have many clinical significances. Although there are several body follicles, the ovarian follicle is the most well-known type. Many other forms of follicular patterns are known as (follicular dendritic cells in the lymph node, follicular stellate cells in the pituitary, etc….) but they are not focused yet. So, we designed this study to define and locate other types of body follicles and correlate their structure and functions. We carried out a search of textbooks, studies cited in google scholar and PubMed up to 2022. The main anatomical, histological, and physiological characteristics of the various human body follicle types were compiled in this review, along with an examination of the distribution of body follicles and the clinical relevance of their various configurations. Conclusion: this review could be the basis for improvement and progression in the field of research on human body follicles.

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Regulation of Male and Female Reproductive Functions

Cited by 8 publications

References 101 publications

Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice

Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice

Targeting Human progesterone receptor (PR), through Pharmacophore- based screening and molecular simulation revealed potent inhibitors against breast cancer

Structural variations and distributions of human Body follicles

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