Regulation of melanocortin 1 receptor in allergic rhinitis <i>in vitro</i> and <i>in vivo</i>

Kleiner, Svea; Braunstahl, Gert‐Jan; Rüdrich, Urda; Gehring, Manuela; Luger, Thomas A.; Steelant, Brecht; Seys, Sven; Kapp, Alexander; Böhm, Markus; Hellings, Peter W.; Raap, Ulrike

doi:10.1111/cea.12759

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…MC1R, a G-protein coupled receptor, has gained attention due to its roles in a number of important physiological processes, including modulation of skin color, defense behavior and inflammatory responses [31,32]. For example, Johannes et al found increased protein and mRNA levels of MC1R on murine podocytes which were treated with puromycin [33].…”

Section: Discussionmentioning

confidence: 99%

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Ocak

et al. 2020

Neurotherapeutics

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Neuroinflammation plays a vital role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). The hypothesis of this study was that activation of melanocortin 1 receptor (MC1R) with BMS-470539 attenuates EBI by suppression of neuroinflammation after SAH. We utilized BMS-470539, MSG-606, and MRT-68601 to verify the neuroprotective effects of MC1R. We evaluated brain water content, short-term and long-term neurobehavior after SAH. Western blotting and immunofluorescence staining were utilized to assess the changes of protein levels. The results of western blotting suggested that the expressions of MC1R, phosphorylated-adenosine monophosphate-activated protein kinase (p-AMPK), and phosphorylated-TANK binding kinase 1 (p-TBK1) were increased and reached their peak points at 24 h following SAH. Moreover, BMS-470539 treatment notably attenuated neurological deficits caused by SAH, and also notably improved long-term spatial learning and memory abilities after SAH. The underlying mechanisms of the neuroprotection of BMS-470539 involved the suppression of microglia activation, promotion of CD206+ microglia transformation and reduction of neutrophil infiltration by increasing the levels of p-AMPK and p-TBK1 while decreasing the levels of NF-κB, IL-1β, and TNFα. The neuroprotective effects of BMS-470539 were significantly abolished by MSG-606 and MRT-68601. The activation of MC1R with BMS-470539 notably attenuates EBI after SAH by suppression of microglial activation and neutrophil infiltration via the AMPK/TBK1/NF-κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Ocak

et al. 2020

Neurotherapeutics

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“…With the growing body of evidence demonstrating the role of MC1R regulation in the treatment of allergic rhinitis and asthma, the effect of α-MSH supplementation in immunological regulation in allergic conjunctivitis has been recently explored [113,114]. Kleiner et al demonstrated that, upon allergen exposure, patients with allergic rhinitis had an accumulation of MC1R-positive basophils in the nasal mucosa.…”

Section: α-Msh Application In the Corneamentioning

confidence: 99%

“…Kleiner et al demonstrated that, upon allergen exposure, patients with allergic rhinitis had an accumulation of MC1R-positive basophils in the nasal mucosa. In vitro, the upregulation of CD203c by anti-IgE was suppressed upon α-MSH supplementation [113]. Webering et al showed that the neutralization of α-MSH in a murine model of asthma led to increased mucus production and airway inflammation.…”

Section: α-Msh Application In the Corneamentioning

confidence: 99%

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Wang,

Kahale,

Naderi

et al. 2024

Biomolecules

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Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases.

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“…5 We previously demonstrated that MC1R-expressing basophils are present in the nasal mucosa of patients with rhinitis following allergen provocation. 6 In this context, the close spatial proximity of basophils with other immune cells in the mucosal tissue permits modulation of ongoing allergic inflammation.…”

Section: To the Editormentioning

confidence: 99%

Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone

Kleiner

Rüdrich

Gehring

et al. 2021

Journal of Allergy and Clinical Immunology

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Regulation of melanocortin 1 receptor in allergic rhinitis in vitro and in vivo

Cited by 7 publications

References 35 publications

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone

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