Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone

Kleiner, Svea; Rüdrich, Urda; Gehring, Manuela; Loser, Karin; Nzeteu, Gaetan Aime Noubissi; Patsinakidis, Nikolaos; Meyer, N. Helge; Gibbs, Bernhard F.; Raap, Ulrike

doi:10.1016/j.jaci.2020.12.645

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Thus, we focus here on other hormones, beyond those of the classical stress response (ACTH and glucocorticoids), which are secreted to the periphery during stress. For example, the pituitary secretes alpha-melanocyte stimulating hormone (Lookingland et al, 1991), a neuropeptide known for its anti-inflammatory effects (Zhang et al, 2020a;Kleiner et al, 2021). Arginine vasopressin (AVP) controls resorption of water in the renal ducts and can influence the regulation of ACTH secretion by the pituitary gland to impact the brain-induced stress response (Zelena et al, 2009;Gray et al, 2012).…”

Section: The Mediators: Endocrine and Neuronal Pathwaysmentioning

confidence: 99%

The neuroimmune response during stress: A physiological perspective

Haykin

Rolls

2021

Immunity

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Section: The Mediators: Endocrine and Neuronal Pathwaysmentioning

confidence: 99%

The neuroimmune response during stress: A physiological perspective

Haykin

Rolls

2021

Immunity

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“…However, basophils manifest both pro-inflammatory and pro-resolving properties in models of chronic skin allergic inflammation(Egawa et al ., 2013) or acute atopic dermatitis(Pellefigues, Naidoo, et al ., 2021). They can control the extent or amplitude of inflammation through various mechanisms(Miyake, Ito and Karasuyama, 2022; Poto et al ., 2023), including extracellular ATP degradation(Tsai et al ., 2015) and secretion of anti-inflammatory mediators such as retinoic acid(Hachem et al ., 2023), IL-10(Kleiner et al ., 2021), or the type 2 cytokines IL-4 and IL-13 (Pellefigues, Mehta, et al ., 2021). Basophils are the main source of IL-4 in models of helminth infection(van Panhuys et al ., 2011), atopic dermatitis(Pellefigues, Naidoo, et al ., 2021; Leyva-Castillo et al ., 2022; Takahashi et al ., 2023) or skin infection(Leyva-Castillo et al ., 2021).…”

Section: Introductionmentioning

confidence: 99%

Basophils drive the resolution and promote wound healing in adult and aged mice

Bex,

Peter,

Saji

et al. 2024

Preprint

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An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils infiltrate the periphery of mouse skin wounds for at least three weeks, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis in the wounds. Basophil-derived IL-4 and M-CSF drive partly their immunoregulatory and healing properties. Unexpectedly, aged mice basophils infiltrate more potently the wounds to promote inflammation resolution, showing a transcriptomic signature biased towards tissue remodeling. Thus, basophils are not pro-inflammatory but pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly.SUMMARYThe resolution of inflammation is essential for homeostasis and becomes defective with age. Here we show basophil immunoregulatory properties promote resolution during skin wound healing, in both adult and aged mice.

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“…Antibody-unrelated pathways of activation include cytokines like IL-3 and thymic stromal lymphopoietin (TSLP) [23], proteases [24], and pathogen-associated stimuli like glycoproteins [25,26]. Although basophils most often exhibit pro-inflammatory properties, evidence is emerging that, in some cases, they might also be capable of inducing anti-inflammatory effects, such as releasing interleukin 10 (IL-10) [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients

Gray

Limberg

Wiebe

et al. 2022

IJMS

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Basophils are key effector cells in atopic diseases, and the signaling sphingolipid Sphigosine-1-phosphate (S1P) is emerging as an important mediator in these conditions. The possible interaction of S1P and basophils and the resulting biological effects have not yet been studied. We hypothesize that S1P influences the function of basophils in atopy and aim to elucidate the modes of interaction. S1P receptor (S1PR) expression in human peripheral blood basophils from atopic and non-atopic patients was assessed through qRT-PCR and flow cytometry analysis. Functional effects of S1P were assessed through a basophil activation test (BAT), calcium flux, apoptosis, and chemotaxis assays. Immunofluorescence staining was performed to visualize intracellular S1P. Human basophils express S1PR1, S1PR2, S1PR3, and S1PR4 on the mRNA level. 0.1 µM S1P have anti-apoptotic, while 10 µM exhibits apoptotic effects on basophils. Basophils from atopic patients show less chemotactic activity in response to S1P than those from healthy donors. Protein expression of S1PR1 is downregulated in atopic patients, and basophils in lesional AD skin possess intracellular S1P. These findings suggest that the interaction of S1P and basophils might be an important factor in the pathophysiology of atopy.

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Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone

Cited by 6 publications

References 10 publications

The neuroimmune response during stress: A physiological perspective

The neuroimmune response during stress: A physiological perspective

Basophils drive the resolution and promote wound healing in adult and aged mice

Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients

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