The neuroimmune response during stress: A physiological perspective

Haykin, Hedva; Rolls, Asya

doi:10.1016/j.immuni.2021.08.023

Cited by 53 publications

(27 citation statements)

References 150 publications

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“…Expression of these components of the GABAergic system in the NTS may play an important role in the regulation of stress-induced escalations in alcohol consumption. [75]…”

Section: Discussionmentioning

confidence: 99%

“…Expression of these components of the GABAergic system in the NTS may play an important role in the regulation of stress-induced escalations in alcohol consumption. [75] While the overarching aim of this study was to identify mediators of stress-induced excessive alcohol consumption, we were also able to identify a potential target for dependence-induced elevations in alcohol consumption using the two CIE-treated groups. A clear pattern emerged across all analyses pointing to type I IFN signaling as a mediator of dependence-induced escalations in alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

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Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract

Grantham

Tiwari

Ponomereva

et al. 2022

Preprint

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Stress exposure contributes to the development of drug and alcohol use disorders. In animal models, stress exacerbates escalations in alcohol consumption in alcohol-dependent animals. The nucleus of the solitary tract (NTS) is a critical brainstem region for integrating and relaying peripheral signals to regulate stress responses. To define the molecular adaptions within this brain region that may contribute to stress-induced alcohol drinking, we exposed animals to chronic intermittent bouts of ethanol vapor (CIE), forced swim stress (FSS), or both (CIE + FSS) and then transcriptionally profiled the NTS at three different timepoints after the last vapor exposure (0-hr, 72-hr, and 186-hr). We identified interferon (IFN) signaling as a critical gene network correlated with alcohol consumption levels. Using a likelihood ratio test, we identified genes that were differentially expressed across time and between groups. Clustering analysis of these genes to identify unique expression patterns identified a subset of genes that fail to normalize in the CIE + FSS group, but not the others. These genes were enriched for cell-to-cell interaction and cellular movement pointing to long-term structural and functional changes in this brain region caused by the unique interaction of alcohol dependence and stress. Specific genes of interest identified in this group include Aqp4, Il16, Reln, Grm4, Gabrd, and Gabra6. We also compared gene expression changes in the NTS to the PFC and found a significant overlap of genes between the two brain regions. Overlapping NTS/PFC genes in the CIE + FSS group were enriched for type I IFN signaling. Finally, we tested the hypothesis that activation of type I IFN signaling increases alcohol consumption based on the three lines of evidence identifying type I IFN signaling as critical for escalations in alcohol intake. Mice treated with recombinant IFNβ showed significantly elevated levels of alcohol intake in a two-bottle choice procedure compared to saline-treated controls. Overall, these results define the transcriptomic changes across time in the NTS that may be critical to the development of stress-induced increases in alcohol consumption and alcohol dependence.

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“…Expression of these components of the GABAergic system in the NTS may play an important role in the regulation of stress-induced escalations in alcohol consumption. [75]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract

Grantham

Tiwari

Ponomereva

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Additionally, studying biobehavioral relationships in the context of HCT is inherently challenging ( Kelly et al, 2021 ), as the dynamic and profound immunologic derangements of the peri-transplant period may obscure more subtle associations between PROs and inflammatory markers. Neuroimmune signaling mechanisms are complex and influenced by a multitude of factors, including an organism's inflammatory milieu and psychosocial/environmental context ( Haykin and Rolls 2021 ). We know that IL-6 and CRP are interrelated ( Bermudez et al, 2002 ), and recent discoveries in immunology have shown that these are pleiotropic molecules that orchestrate not only inflammation, but also tissue regeneration, metabolism, and homeostasis ( Del Giudice and Gangestad 2018 ; Kang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of tocilizumab on patient reported outcomes and inflammatory biomarkers in hematopoietic cell transplantation

Taylor

Hillard

Drobyski

et al. 2022

Brain, Behavior, & Immunity - Health

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“…AID is really a multifunctional disease, which is consistent with the human iron‐proteome [ 58 , 59 ]. Exploration of iron metabolism in the CNS would be necessary for a good understanding of the relation between iron and neurodegenerative diseases, iron and the psychological status, iron and depression, continuous and chronic brain low‐grade inflammation [ 60 ] and iron metabolism. Anemic syndrome alone could impact cognitive and psychomotor functions in addition to the potential effects of I‐AID.…”

Section: Discussionmentioning

confidence: 99%

Iron, neuro‐bioavailability and depression

Berthou

Iliou²,

Barba³

2021

eJHaem

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Medical management of iron deficiency (ID) requires to consider its consequences in biochemical and physiological plural functions, beyond heme/hemoglobin disrupted synthesis. Fatigue, muscle weakness, reduced exercise capacity, changes in thymia and modified emotional behaviors are the commonest symptoms integrated in the history of ID, dependent or not of the hemoglobin concentration. The relationship between depression and absolute ID (AID) is a condition which is often unrecognized. Neuro‐bioavailability and brain capture of blood iron are necessary for an appropriate synthesis of neurotransmitters (serotonin, dopamine, noradrenaline). These neurotransmitters, involved in emotional behaviors, depend on neuron aromatic hydoxylases functioning with iron as essential cofactor. Noradrenaline also has impact on neuroplasticity via brain‐derived neurotrophic factor (BDNF), which is key for prefrontal and hippocampus neurons playing a role in depression. Establishing the formal relationship between depression and AID remains difficult. Intracerebral reduced iron is still hard to quantify by neuroimaging and single‐photon emission computed tomography (SPECT) now tends to explore the neurotransmission pathways. AID has to be looked for and identified in the context of depression, major episode or resistant to conventional treatment such as serotonin reuptake inhibitor, and even in the absence of anemia, microcytosis or hypochromia (non‐anemic ID). Confronted to brain imaging, blood iron status evaluation is indicated, especially in depressed, treatment‐resistant, iron‐deficient young women. In patients suffering from depression, increase in the prevalence of AID should be considered, in order to deliver a suitable treatment, considering both anti‐depressive program and iron supplementation if AID.

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The neuroimmune response during stress: A physiological perspective

Cited by 53 publications

References 150 publications

Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract

Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract

The effect of tocilizumab on patient reported outcomes and inflammatory biomarkers in hematopoietic cell transplantation

Iron, neuro‐bioavailability and depression

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