Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review

Sun, Tianning; Mao, Feng; Manyande, Anne; Xiang, Hong‐Bing; Xiong, Jun; He, Zhigang

doi:10.3389/fnins.2023.1206417

Cited by 2 publications

(1 citation statement)

References 142 publications

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“…Magnetic resonance spectroscopy (MRS) has been used extensively as a non-invasive tool to evaluate brain metabolic changes in patients with cirrhosis (33,34). For example, previous 1 H-MRS studies have focused on anterior cingulate gyrus; frontal, parietal, and occipital lobes; and the basal ganglia (35-37).…”

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confidence: 99%

Metabolic alterations in the right anterior insula among patients with cirrhosis without overt hepatic encephalopathy: a magnetic resonance spectroscopy study

Huang,

Dong

et al. 2024

Front. Neurol.

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PurposeWe investigated metabolic alterations in the right anterior insula (rAI) in cirrhotic patients and determined its association with patients' cognitive dysfunction.MethodsIn this study, 31 healthy controls (HCs) and 32 cirrhotic patients without overt hepatic encephalopathy participated. Both blood ammonia level and Child-Pugh score were measured. The psychometric hepatic encephalopathy score (PHES) was used to evaluate cognitive function. 1H-magnetic resonance spectroscopy (MRS) data located in the rAI were recorded on a commercially available 3T magnetic resonance imaging scanner. The ratios of metabolites were measured, including N-acetylaspartate (NAA)/total creatine (tCr), glutamate plus glutamine (Glx)/tCr, myo-inositol (mI)/tCr, and total choline (tCho)/tCr. We adopted the non-parametric Mann–Whitney U-test for intergroup comparison of metabolic ratios. To determine the association between metabolite concentration and clinical parameters, we performed Spearman correlation analyses.ResultsPatients with cirrhosis performed worse on PHES in comparison with HCs (P < 0.001). Patients with cirrhosis had significantly decreased mI/tCr (0.87 ± 0.07 vs. 0.74 ± 0.19, P = 0.025) and increased Glx/tCr (1.79 ± 0.17 vs. 2.07 ± 0.29, P < 0.001) in the rAI. We did not observe any significant between-group differences in tCho/tCr and NAA/tCr. The blood ammonia level was correlated with Glx/tCr (r = 0.405, P = 0.022) and mI/tCr (r = −0.398, P = 0.024) of the rAI. In addition, PHES was negatively correlated with Glx/tCr of the rAI (r = −0.379, P = 0.033).ConclusionMetabolic disturbance of the rAI, which is associated with ammonia intoxication, might account for the neural substrate of cirrhosis-related cognitive dysfunction to some extent.

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Section: Introductionmentioning

confidence: 99%

Metabolic alterations in the right anterior insula among patients with cirrhosis without overt hepatic encephalopathy: a magnetic resonance spectroscopy study

Huang,

Dong

et al. 2024

Front. Neurol.

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Innovative Design and Experimental Research of the Patient Transfer Apparatus for MRI Room

Sang,

Liu,

Wang

et al. 2024

MENG

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Background: Patient Transfer Apparatus (PTA), which has been reported by various relevant papers and patents, is widely used in the hospital. However, there are few corresponding transfer apparatuses for research and development in the nuclear magnetic resonance imaging (MRI) room because of the influence of a high magnetic field environment. It is desired to require the apparatus for the patient and the medical staff to have weak magnetism, high matching, and easy operation, etc Objective: The purpose of this study is to find out the working principle of PTA, to conduct parameter optimization and design and develop more effective PTA for the application of the MRI room. Methods: Firstly, based on the patient transfer process, a novel transfer model with the coordinated movement of the transfer belt and the moving panel is proposed, the corresponding clutch mechanism is conceived and the working principle of the whole mechanism movement is designed and analyzed in detail. Secondly, the force analysis of the clutch mechanism, lifting mechanism and patient transfer mechanism are performed, the mechanical structures are optimized, and the optimal sizes are obtained. Thirdly, the mechanical structure of the system is designed in detail, and the prototype is manufactured. Results: Finally, the performance evaluation of the system is conducted by means of the fuzzy evaluation method and clinical study. The results showed that the motion function of the apparatus is reasonable and it can work normally in the MRI room, the comfort of the PTA is also excellent. The research results also prove the accuracy of the working principle and the rationality of the structural design Conclusion: The non-magnetic PTA is suitable for quickly transferring patients who are unable to move in the MRI room of a hospital by the manual method

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Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review

Cited by 2 publications

References 142 publications

Metabolic alterations in the right anterior insula among patients with cirrhosis without overt hepatic encephalopathy: a magnetic resonance spectroscopy study

Metabolic alterations in the right anterior insula among patients with cirrhosis without overt hepatic encephalopathy: a magnetic resonance spectroscopy study

Innovative Design and Experimental Research of the Patient Transfer Apparatus for MRI Room

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