“…The sequence near the m6A modification site on the mRNA is highly conservative, mainly occurring on the adenine of the RRACH (R: purine; A: m 6 A; H: non-guanine) sequence, and its function is determined by the methyltransferase (writers: methyltransferase like 3 (METTL3), methyltransferase like 14 (METTL14) and WT1 associated protein (WTAP), et al), demethylase (erasers: fat mass and obesity associated protein (FTO) and alkB homologue 5 (ALKBH5), et al) and binding protein (readers: YTH domain containing family, the insulin like growth factor 2 mRNA binding protein (IGF2BP) family and heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), et al) are jointly regulated ( Yang et al, 2018 ; Li M. et al, 2021 ). M 6 A modification is involved in a variety of biological processes, such as stem cell differentiation, cell division, gametogenesis and biological rhythms, et al, as well as the occurrence of a variety of diseases, including tumors, obesity and infertility ( Xu Y. et al, 2020 ; Zhang M. et al, 2020 ; Song et al, 2020 ). M 5 C modification is another prevalent RNA modification in multiple RNA species, including mRNAs, tRNAs, rRNAs, and ncRNAs ( Chen et al, 2021 ).…”