Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases

Obradović, Milan; Stanimirović, Julijana; Panic, Anastasija; Bogdanovic, Nikola; Sudar-Milovanović, Emina; Cenić-Milošević, Desanka; Isenović, Esma R.

doi:10.2174/1381612823666170203113455

Cited by 18 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reduced levels of Na + /K + -ATPase with altered Na + and Ca 2+ ionic homeostasis can stimulate proteases and phospholipases including those which initiate apoptosis, myocardial damage, and failure (Agrawal et al 2016;Khatua et al 2017). Hence, controlling of Na + /K + -ATPase activity is essential for prevention of cardiac diseases (Obradovic et al 2017). Interestingly, GE treatment in this study restored Na + /K + -ATPase activity and Ca 2+ levels towards normal values possibly by protecting the membrane structures via its antioxidant activity and/or control of its gene activity.…”

Section: Discussionmentioning

confidence: 99%

“…The sodium/potassium-adenosine-triphosphatase (Na + /K + -ATPase) plays a key role in myocardial contractility through regulating the concentration of ions inside and outside cells. Therefore, the activity of Na + /K + -ATPase is a principal biomarker for cardiac diseases and essential for studying treatment and prevention modalities (Obradovic et al 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Gomaa

Abdelhafez

Aamer

2018

Cell Stress and Chaperones

View full text Add to dashboard Cite

Gentamicin (GNT)-induced nephrotoxicity culminates into renal failure with a possible cardiovascular impact. Garlic extract (GE) is a cardiovascular protectant with limited mechanistic data. Therefore, we assessed the disturbance in specific cardiac parameters and the potential protective effect of GE supplementation against them in a rat model of GNT-induced chronic renal failure (CRF). Adult male rats (n = 24) were randomly assigned into four groups (n = 6 each): normal controls (CON), garlic extract controls (GE; 250 mg kg, orally), GNT-induced CRF (GNT; 100 mg kg, i.p.), and GNT + GE (GNT and GE in the same previous doses) groups. GNT and GE were given daily for 3 weeks. Animals co-treated with GNT and GE exhibited improved renal functions, body weight (BW), and heart weight (HW)/BW ratio; declined blood pressure; lowered plasma levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and total peroxides (TP); and elevated total antioxidant capacity (TAC) levels. Moreover, the heart tissue contained raised levels of TAC and Na/K-ATPase activity and lowered levels of TP and Ca. Findings provide evidence that administration of GE in experimental CRF model helped protect the heart through reducing oxidative stress and controlling cardiac Na/K-ATPase activity and Ca levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Gomaa

Abdelhafez

Aamer

2018

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus (DM) is a carbohydrate metabolism disorder characterized by alterations and impairment in insulin secretion and/or action that leads to hyperglycaemia (Ergun-Longmire and Maclaren 2000;ADA 2009;Lebovitz 1984). Besides the increased blood glucose level, DM is also characterized by other biochemical disorders arising as a consequence of inadequate regulation of insulin synthesis/ actions which all together contribute to progression of the disease and its association with long-term injury, dysfunction, and failure of different organs, especially the blood vessels and heart (Jovanovic et al 2017;Obradovic et al 2017;Sudar Milovanovic et al 2015;Sudar-Milovanovic et al 2017;Obradovic et al 2015;Soskic et al 2011) but also the nerves, kidneys, and eyes (ADA 2009). Study results obtained in the field of genetics, epidemiology, etiology, and pathophysiology of DM states, showed that diabetes is not a single disease, but preferably a clinical disorder with a set of various medical signs and symptom and primarily identified by an improper increase of fasting and/or postprandial serum/plasma glucose level accompanied by the development and spreading of long-term micro-and macro-vascular, as well as neuropathic alterations (Lebovitz 1984).…”

Section: Aetiology and Pathophysiology Of Dmt1 And Dmt2mentioning

confidence: 99%

Diabetes and Treatments

Obradović¹,

Sudar-Milovanović²,

Gluvić

et al. 2020

Obesity and Diabetes

Self Cite

View full text Add to dashboard Cite

The diabetes pandemic demands solutions for proper glycemic control and prevention of future chronic complications that could result in organ failure or comorbidities. In this regard, we now know that patients diagnosed with diabetes require individual management plans. Thus, new treatment management strategies have been designed to allow clinicians to tailor the most appropriate therapy for diabetes patients individually. These treatment management plans extend beyond defining the appropriate medications for patients; they provide a directive toward some acute and chronic complications that should be screened for, as they are historically known to occur with diabetes. Observing any of the complications or comorbidities required the patient medication regimen to be adapted accordingly. This chapter describes such modern treatment plans for the two primary forms of diabetes, type 1 and type 2, based on both basic and clinical studies, later incorporated in various diabetes management guidelines and outlines expected future trends.

show abstract

“…Свободные жирные кислоты также могут активировать фосфорилирование кальцийнезависимый изофермент протеинкиназы С, важный элемент клеточной регуляции. Связывание свободных жирных кислот с Na + /K + -АТФ-азой приводит к формированию множественных сигнальных модулей [26], в результате чего происходит активация и синтез рецептора эпидермального фактора роста и увеличение концентрации активных форм кислорода [27]. Изменения функции эндотелия являются результатом снижения синтеза NO вследствие активации оксидативного стресса или под действием провоспалительных цитокинов [28].…”

Section: ожирение как мощный фактор риска артериальной гипертензии у молодых лицunclassified

Mechanisms for the development of arterial hypertension in overweight adolescents and young adults

Мустафаева¹

2019

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

In recent years, an increase in the number of young people with arterial hypertension (AH) has occurred together with the increased prevalence of obesity. It is generally recognized that obesity plays an important role in the pathogenesis of hypertension in adolescents and young adults. In adolescents of non-European ethnicity with a family history of disease, a low birth weight and sedentary lifestyle, and insufficient physical activity and poor sleep quality, excess weight is accompanied by a high probability of AH. High tolerance to cardio-respiratory exertion and a number of genetic polymorphisms can play a protective role against this pathology. Biochemical studies in young people with hypertension and excess weight display a number of features, including levels of hormones and enzymes of the renin-angiotensin system, associated with lipid metabolism and inflammation. Adolescents with hypertension can be included in the group of young people at high risk of damage to affected organs and the subsequent development of cardiovascular diseases, based on a number of characteristics: blood pressure readings, BMI, age, family history and ethnicity.

show abstract

Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases

Abstract: Understanding the molecular mechanisms of estradiol and IGF-1 action on Na+/K+-ATPase in humans, may help resolving outstanding issues and developing new strategies for the protection and treatment of cardiovascular diseases.

Cited by 18 publications

References 0 publications

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels

Diabetes and Treatments

Mechanisms for the development of arterial hypertension in overweight adolescents and young adults

Contact Info

Product

Resources

About